Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21455436 | 0.85 | MEN1 (0.37) | TSHRPKMMEN1MAPTHPGD | |
| SCHEMBL21456022 | 0.84 | AGBL2 (0.46) | AGBL2CXCL8TSHRCAMK2ARXRA | |
| SCHEMBL21455754 | 0.83 | HSD17B10 (0.54) | CAMK2AHSD17B10MEN1MAPTKMT2A | |
| SCHEMBL14125958 | 0.76 | HSD17B10 (0.54) | AGBL2CXCL8TSHRCAMK2AHSD17B10 | |
| SCHEMBL29530799 | 0.76 | HSD17B10 (0.54) | AGBL2CXCL8TSHRCAMK2AHSD17B10 | |
| SCHEMBL24200174 | 0.74 | MEN1 (0.37) | TSHRPKMMEN1MAPTHPGD | |
| SCHEMBL23229181 | 0.72 | AGBL2 (0.41) | AGBL2CXCL8TSHRRXRAPKM | |
| SCHEMBL29116956 | 0.71 | SLC6A4 (0.38) | TSHRMEN1MAPTHPGDKMT2A | |
| SCHEMBL22867120 | 0.70 | AGBL2 (0.52) | AGBL2CXCL8TSHRRXRASRC | |
| SCHEMBL18642464 | 0.70 | CXCL8 (0.45) | CXCL8TSHRCAMK2APKMFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195720-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |