Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | PPM1B | O75688 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22230562 | 1.00 | CHRNB2 (0.49) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL19284970 | 1.00 | CHRNB2 (0.49) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL23688029 | 1.00 | CHRNB2 (0.49) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL13479230 | 0.91 | CHRNB2 (0.50) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL21458096 | 0.85 | PPM1B (0.45) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL21458055 | 0.81 | CHRNB2 (0.51) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL21458031 | 0.81 | CHRNB2 (0.51) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL21458033 | 0.81 | CHRNB2 (0.51) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL13286850 | 0.80 | PPM1B (0.56) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B | |
| SCHEMBL9368031 | 0.79 | CHRNB2 (0.50) | CHRNB2CHRNA5CHRNA7CHRNA4PPM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315731-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS, LTD. (CH) | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315731-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | TMBIM6, BTN3A1, BET1 | CHRNB2 4778/4885CHRNA5 4720/4885CHRNA7 4715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.