Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 6/20 | 0.46 |
| ▸ | SCN8A | Q9UQD0 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21458102 | 0.89 | MEN1 (0.88) | MEN1HTTRAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL21458101 | 0.89 | MEN1 (0.88) | MEN1HTTRAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL21458104 | 0.89 | MEN1 (0.88) | MEN1HTTRAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL12790000 | 0.83 | MEN1 (1.00) | MEN1HTTRAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL18962385 | 0.72 | MEN1 (0.72) | MEN1HTTRAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL5744517 | 0.71 | ALDH1A1 (0.56) | MEN1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL16090511 | 0.71 | MEN1 (0.74) | MEN1HTTRAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL1604026 | 0.70 | LMNA (1.00) | MEN1HTTRAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL19317179 | 0.70 | MEN1 (0.67) | MEN1HTTRAB9ARXFP1SMN1; SMN2 | |
| SCHEMBL12533520 | 0.69 | MEN1 (0.66) | MEN1HTTRAB9ARXFP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10966981-B2 | Fatty acid synthase inhibitors | DUKE UNIVERSITY (US) | 2021-04-06 | — | — | US | disclosed |
| US-20190314376-A1 | FATTY ACID SYNTHASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-10-17 | — | — | US | disclosed |