Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975598 | 0.92 | MEN1 (0.53) | HSD11B1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL23022742 | 0.92 | HSD11B1 (0.59) | HSD11B1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL5316077 | 0.83 | KMT2A (0.53) | HSD11B1KMT2AMEN1MGLLALDH1A1 | |
| SCHEMBL2146383 | 0.79 | HSD11B1 (0.54) | HSD11B1KMT2AMEN1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL10640478 | 0.78 | KMT2A (0.65) | HSD11B1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL3965621 | 0.77 | KDM2B (0.66) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL3895577 | 0.75 | HSD11B1 (0.69) | HSD11B1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL5475032 | 0.75 | ALDH1A1 (0.59) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL969184 | 0.75 | ALDH1A1 (0.59) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL969182 | 0.75 | ALDH1A1 (0.59) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |