Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 11/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145821 | 0.92 | HSD11B1 (0.53) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL3965621 | 0.85 | KDM2B (0.66) | MEN1KMT2AALDH1A1KDM2B | |
| SCHEMBL23022742 | 0.84 | HSD11B1 (0.59) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL4079510 | 0.81 | KDM2B (0.44) | MEN1KMT2AALDH1A1KDM2BMGLL | |
| SCHEMBL969184 | 0.80 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5475032 | 0.80 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1 | |
| SCHEMBL27778359 | 0.80 | KMT2A (0.52) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL969182 | 0.80 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4082779 | 0.80 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL23579339 | 0.78 | HSD11B1 (0.58) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |