Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.52 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146162 | 1.00 | SLC6A1 (0.52) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| Hydrochloric Acid SCHEMBL2146235 | 0.98 | SLC6A1 (0.50) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| Hydrochloric Acid SCHEMBL2146240 | 0.98 | SLC6A1 (0.50) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| SCHEMBL9253898 | 0.89 | TSHR (0.54) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| SCHEMBL30479173 | 0.89 | CHRNB2 (0.52) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| SCHEMBL28023799 | 0.89 | GABRA5 (0.52) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| SCHEMBL28824479 | 0.89 | GABRA5 (0.52) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| Hydrochloric Acid SCHEMBL25342371 | 0.86 | CHRNB2 (0.50) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| SCHEMBL27643059 | 0.86 | SLC6A1 (0.61) | SLC6A1TSHRSLC6A11SLC6A13LMNA | |
| SCHEMBL11126760 | 0.86 | TSHR (0.56) | SLC6A1TSHRSLC6A11SLC6A13LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |