Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 19/20 | 0.41 |
| ▸ | AURKA | O14965 | 16/20 | 0.41 |
| ▸ | AURKC | Q9UQB9 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148465 | 0.92 | AURKB (0.43) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2146309 | 0.87 | AURKB (0.55) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2146188 | 0.85 | AURKB (0.51) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2182489 | 0.84 | AURKA (0.56) | AURKBAURKA | |
| SCHEMBL2148630 | 0.83 | AURKA (0.32) | AURKBAURKASRCGSK3B | |
| SCHEMBL2148571 | 0.83 | AURKB (0.48) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2148475 | 0.83 | NPC1 (0.43) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2169729 | 0.78 | AURKB (0.65) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2148917 | 0.78 | AURKB (0.42) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2169274 | 0.78 | AURKB (0.47) | AURKBAURKAAURKCSRCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |