Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.48 |
| ▸ | GABRP | O00591 | 5/20 | 0.45 |
| ▸ | GABRD | O14764 | 5/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.45 |
| ▸ | GABRE | P78334 | 5/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30615578 | 1.00 | AURKA (0.48) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL30615443 | 0.84 | GABRP (0.52) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL30615318 | 0.78 | AURKA (0.55) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL3788615 | 0.77 | AURKA (0.51) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL21463352 | 0.77 | AURKA (0.51) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL28495778 | 0.76 | HSP90AA1 (0.44) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL21464410 | 0.75 | AURKA (0.50) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL30615454 | 0.75 | AURKA (0.50) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL30615405 | 0.75 | HSP90AA1 (0.52) | AURKAHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL30583952 | 0.73 | GABRP (0.56) | AURKAHSP90AA1GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11802120-B2 | Fused cyclic urea derivatives as CRHR2 antagonist | RAQUALIA PHARMA INC. (JP) | 2023-10-31 | — | — | US | disclosed |
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |
| US-20210078975-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC. (JP) | 2021-03-18 | — | — | US | disclosed |
| EP-3774739-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RaQualia Pharma Inc. (JP) | 2021-02-17 | — | — | EP | disclosed |
| CN-111868037-A | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2020-10-30 | — | — | CN | disclosed |
| WO-2019198692-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC. (JP) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078975-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | CRHR2, CRHR1, CRH | AURKA 4740/4885HSP90AA1 1723/4885GABRP 731/4885 |
| US-11802120-B2 | Fused cyclic urea derivatives as CRHR2 antagonist | CRHR2, CRHR1, CRH | AURKA 4740/4885HSP90AA1 1723/4885GABRP 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.