SCHEMBL2146554

SCHEMBL2146554

Cc1cc(CO)c(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 8/20 0.64
RAB9A P51151 8/20 0.64
POLB P06746 2/20 0.57
LMNA P02545 1/20 0.56
KDM4E B2RXH2 5/20 0.47
ALDH1A1 P00352 5/20 0.45
SMN1; SMN2 Q16637 4/20 0.45
HPGD P15428 4/20 0.41
MAPT P10636 4/20 0.41
TDP1 Q9NUW8 2/20 0.41
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
TNF P01375 1/20 0.36
TSHR P16473 1/20 0.36
IGF2BP2 Q9Y6M1 1/20 0.35
THRB P10828 1/20 0.35
BCHE P06276 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL258759 0.89 NPC1 (0.66) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL31267541 0.89 NPC1 (0.66) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL29494818 0.89 NPC1 (0.66) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL10061927 0.88 NPC1 (0.64) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL2146562 0.87 NPC1 (0.67) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL508460 0.87 NPC1 (0.62) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL13288139 0.85 NPC1 (0.61) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL12460438 0.85 NPC1 (0.61) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL7904369 0.85 NPC1 (0.61) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL29520058 0.85 NPC1 (0.61) NPC1RAB9APOLBLMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7101943-A None JP disclosed
JP-8208628-A None JP disclosed
EP-2523942-B1 2-Phenyl-1,2,3-benzotriazoles for UV radiation absorbance DSM IP ASSETS BV (NL) 2015-02-25 EP disclosed
EP-2523942-B1 2-Phenyl-1,2,3-benzotriazoles for UV radiation absorbance DSM IP ASSETS BV (NL) 2015-02-25 EP disclosed
US-8895754-B2 Process to make UV radiation absorbing 2-phenyl-1,2,3,-benzotriazoles DSM IP ASSETS B.V. (NL) 2014-11-25 US disclosed
US-8895754-B2 Process to make UV radiation absorbing 2-phenyl-1,2,3,-benzotriazoles DSM IP ASSETS B.V. (NL) 2014-11-25 US disclosed
US-8895754-B2 Process to make UV radiation absorbing 2-phenyl-1,2,3,-benzotriazoles DSM IP ASSETS B.V. (NL) 2014-11-25 US disclosed
CN-102712605-B Process to make UV radiation absorbing 2 - phenyl - 1, 2, 3 - benzotriazoles DSM IP ASSETS BV 2014-11-12 CN disclosed
CN-102791698-B 2-phenyl-1,2,3-benzotriazoles for UV radiation absorbance DSM IP ASSETS BV 2014-11-12 CN disclosed
US-8883829-B2 2-phenyl-1,2,3-benzotriazoles for UV radiation absorbance DSM IP ASSETS B.V. (NL) 2014-11-11 US disclosed
EP-2523943-A1 PROCESS TO MAKE UV RADIATION ABSORBING 2 - PHENYL - 1, 2, 3 - BENZOTRIAZOLES DSM IP Assets B.V. (NL) 2012-11-21 EP disclosed
EP-2523942-A1 2 - PHENYL - 1, 2, 3 - BENZOTRIAZOLES FOR UV RADIATION ABSORBANCE DSM IP Assets B.V. (NL) 2012-11-21 EP disclosed
CN-102791698-A 2-phenyl-1,2,3-benzotriazoles for UV radiation absorbance DSM IP ASSETS BV 2012-11-21 CN disclosed
CN-102712605-A Process to make UV radiation absorbing 2 - phenyl - 1, 2, 3 - benzotriazoles DSM IP ASSETS BV 2012-10-03 CN disclosed
WO-2011086124-A1 2 - PHENYL - 1, 2, 3 - BENZOTRIAZOLES FOR UV RADIATION ABSORBANCE DSM IP ASSETS B.V. (NL) 2011-07-21 WO disclosed
WO-2011086124-A1 2 - PHENYL - 1, 2, 3 - BENZOTRIAZOLES FOR UV RADIATION ABSORBANCE DSM IP ASSETS B.V. (NL) 2011-07-21 WO disclosed
WO-2011086127-A1 PROCESS TO MAKE UV RADIATION ABSORBING 2 - PHENYL - 1, 2, 3 - BENZOTRIAZOLES DSM IP ASSETS B.V. (NL) 2011-07-21 WO disclosed
WO-2011086127-A1 PROCESS TO MAKE UV RADIATION ABSORBING 2 - PHENYL - 1, 2, 3 - BENZOTRIAZOLES DSM IP ASSETS B.V. (NL) 2011-07-21 WO disclosed
JP-H08208628-A BENZOTRIAZOLE AND PRODUCTION THEREOF OSAKA SEIKA KOGYO KK 1996-08-13 JP disclosed
JP-H07101943-A NEW BENZOTRIAZOLE COMPOUND AND ITS PRODUCTION OSAKA SEIKA KOGYO KK 1995-04-18 JP disclosed