SCHEMBL258759

SCHEMBL258759

Cc1cc(Cc2cc(C)cc(-n3nc4ccccc4n3)c2O)c(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.66
RAB9A P51151 7/20 0.66
POLB P06746 2/20 0.58
LMNA P02545 1/20 0.58
KDM4E B2RXH2 4/20 0.48
ALDH1A1 P00352 5/20 0.46
SMN1; SMN2 Q16637 5/20 0.46
AMY1A P0DUB6 1/20 0.44
MAPT P10636 4/20 0.41
HPGD P15428 3/20 0.41
TDP1 Q9NUW8 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HSPA5 P11021 1/20 0.40
CYP2C9 P11712 3/20 0.39
CYP2C19 P33261 3/20 0.39
HIF1A Q16665 2/20 0.39
CYP1A2 P05177 1/20 0.38
IGF2BP2 Q9Y6M1 1/20 0.36
THRB P10828 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31267541 1.00 NPC1 (0.66) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL29494818 1.00 NPC1 (0.66) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL23050234 0.94 NPC1 (0.59) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL14323153 0.91 NPC1 (0.59) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL14997992 0.91 NPC1 (0.56) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL8962454 0.89 NPC1 (0.54) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL6153043 0.89 HSPA5 (0.60) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL10061927 0.89 NPC1 (0.64) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL2146554 0.89 NPC1 (0.64) NPC1RAB9APOLBLMNAKDM4E
SCHEMBL11373760 0.89 NPC1 (0.57) NPC1RAB9APOLBLMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 625 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080075678-A1 COSMETIC COMPOSITION COMPRISING AN EXTRACT OF EMBLICA OFFICINALIS AND METHODS OF USING SAME L'OREAL 2008-03-27 US claimed
US-7029660-B2 Cosmetic or dermatological light-protective formulation comprising a benzotriazole and a benzoxazole derivative BEIERSDORF AG (DE) 2006-04-18 US claimed
EP-1087870-B1 MULTILAYER PLASTIC ARTICLES GEN ELECTRIC (US) 2006-01-11 EP claimed
US-20050025726-A1 Cosmetic or dermatological light-protective formulation comprising a benzotriazole and a benzoxazole derivative BEIERSDORF AG 2005-02-03 US claimed
US-20040028642-A1 Cosmetic composition comprising an extract of emblica officinalis and methods of using same L'OREAL S.A. (FR) 2004-02-12 US claimed
EP-0899302-B1 Polycarbonate compositions comprising polyester resins and ultraviolet light absorbers GEN ELECTRIC (US) 2003-06-11 EP claimed
EP-1087870-A1 MULTILAYER PLASTIC ARTICLES GENERAL ELECTRIC COMPANY (US) 2001-04-04 EP claimed
WO-1999048685-A1 MULTILAYER PLASTIC ARTICLES GENERAL ELECTRIC COMPANY (US) 1999-09-30 WO claimed
US-12605324-B2 Composition comprising ingredients for DIC-gel and polyol L'OREAL (FR) 2026-04-21 US disclosed
US-20260096969-A1 Compositions Containing a UV-Absorbing System Including Physical UV-Attenuating Material, Trihydroxystearin and Fatty Acid Oil For Inhibiting Trihydroxystearin Crystallization L'OREAL (FR) 2026-04-09 US disclosed
US-20260096964-A1 Emulsions Containing a UV-Absorbing System Including Physical UV-Attenuating Material, Surfactant, and Thickener L'OREAL (FR) 2026-04-09 US disclosed
US-20260096967-A1 Compositions Containing a UV-Absorbing System Including Physical UV-Attenuating Material and Coloring Agent L'OREAL (FR) 2026-04-09 US disclosed
US-20260096974-A1 Compositions Containing a UV-Absorbing System Including Physical UV-Attenuating Material and Oil For Inhibiting Physical UV-Attenuating Material Aggregation L'OREAL (FR) 2026-04-09 US disclosed
US-20260096973-A1 Fluid Emulsion Compositions Containing a UV-Absorbing System Including Physical UV-Attenuating Material, Surfactant, and Thickener L'OREAL (FR) 2026-04-09 US disclosed
EP-0675108-B1 Thioether substituted hydroxybenzophenones and stabilized compositions CIBA GEIGY AG (CH) 1998-06-10 EP disclosed
EP-0821709-A1 POLYKETONE POLYMER COMPOSITION SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1998-02-04 EP disclosed
WO-1996033236-A1 POLYKETONE POLYMER COMPOSITION SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1996-10-24 WO disclosed
EP-0675108-A1 Thioether substituted hydroxybenzophenones and stabilized compositions CIBA-GEIGY AG (CH) 1995-10-04 EP disclosed
US-5439955-A An actinic light resistant blends comprising a 2-benzotriazoyl -benzoyl-benzylphenol stabilizers CIBA-GEIGY CORPORATION (US) 1995-08-08 US disclosed
US-5387691-A Light stabilizers CIBA-GEIGY CORPORATION (US) 1995-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12605324-B2 Composition comprising ingredients for DIC-gel and polyol ALG1, DAD1, DDOST NPC1 2891/4885RAB9A 3881/4885POLB 3385/4885
US-20260096969-A1 Compositions Containing a UV-Absorbing System Including Physical UV-Attenuating Material, Trihydroxystearin and Fatty Acid Oil For Inhibiting Trihydroxystearin Crystallization POT1, TERT, TERF2IP NPC1 455/4885RAB9A 4466/4885POLB 971/4885
US-20050025726-A1 Cosmetic or dermatological light-protective formulation comprising a benzotriazole and a benzoxazole derivative TYR, CUTA, TFEB NPC1 4738/4885RAB9A 4697/4885POLB 1437/4885
US-20260096973-A1 Fluid Emulsion Compositions Containing a UV-Absorbing System Including Physical UV-Attenuating Material, Surfactant, and Thickener APOB, LDLR, MAN2B1 NPC1 950/4885RAB9A 2332/4885POLB 75/4885
US-20260096967-A1 Compositions Containing a UV-Absorbing System Including Physical UV-Attenuating Material and Coloring Agent ERCC1, ERCC5, CUTA NPC1 2050/4885RAB9A 2082/4885POLB 658/4885
US-20260096964-A1 Emulsions Containing a UV-Absorbing System Including Physical UV-Attenuating Material, Surfactant, and Thickener DSG1, XPA, EXOSC10 NPC1 2707/4885RAB9A 2019/4885POLB 112/4885
US-20260096974-A1 Compositions Containing a UV-Absorbing System Including Physical UV-Attenuating Material and Oil For Inhibiting Physical UV-Attenuating Material Aggregation POT1, TERB1, AUP1 NPC1 771/4885RAB9A 3584/4885POLB 275/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.