Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 10/20 | 0.55 |
| ▸ | MERTK | Q12866 | 8/20 | 0.55 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 8/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377664 | 0.83 | AXL (0.72) | AXLMERTKTYRO3 | |
| SCHEMBL29626184 | 0.79 | AXL (0.51) | AXLMERTKACVRL1TYRO3 | |
| SCHEMBL19377714 | 0.69 | AXL (0.79) | AXLMERTKTYRO3 | |
| SCHEMBL19377764 | 0.69 | ACVRL1 (0.64) | AXLMERTKACVRL1 | |
| SCHEMBL29626293 | 0.67 | AXL (0.69) | AXLMERTKACVRL1TYRO3 | |
| SCHEMBL29626306 | 0.67 | ACVRL1 (0.52) | AXLMERTKACVRL1TYRO3 | |
| SCHEMBL29626096 | 0.66 | AXL (0.53) | AXLMERTKACVRL1TYRO3 | |
| SCHEMBL29626256 | 0.65 | AXL (0.52) | AXLMERTKACVRL1TYRO3 | |
| SCHEMBL19377558 | 0.64 | AXL (1.00) | AXLMERTKTYRO3 | |
| SCHEMBL29626141 | 0.64 | AXL (1.00) | AXLMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442810-B2 | Pyrrolotriazine compounds as TAM inhibitors | INCYTE CORPORATION (US) | 2019-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442810-B2 | Pyrrolotriazine compounds as TAM inhibitors | MERTK, MAP3K15, MAP3K5 | AXL 49/4885MERTK 1/4885ACVRL1 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.