Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 12/20 | 0.52 |
| ▸ | AXL | P30530 | 7/20 | 0.51 |
| ▸ | MERTK | Q12866 | 6/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29626096 | 0.88 | AXL (0.53) | ACVRL1AXLMERTKTYRO3 | |
| SCHEMBL29626256 | 0.86 | AXL (0.52) | ACVRL1AXLMERTKTYRO3 | |
| SCHEMBL29626184 | 0.85 | AXL (0.51) | ACVRL1AXLMERTKTYRO3 | |
| SCHEMBL29626293 | 0.83 | AXL (0.69) | ACVRL1AXLMERTKTYRO3 | |
| SCHEMBL19377745 | 0.79 | AXL (0.73) | AXLMERTKTYRO3 | |
| SCHEMBL29626192 | 0.78 | AXL (0.64) | ACVRL1AXLMERTKTYRO3 | |
| SCHEMBL19377764 | 0.78 | ACVRL1 (0.64) | ACVRL1AXLMERTK | |
| SCHEMBL29626243 | 0.74 | AXL (0.66) | AXLMERTKTYRO3 | |
| SCHEMBL29626173 | 0.72 | TYRO3 (0.66) | AXLMERTKTYRO3 | |
| SCHEMBL29626136 | 0.72 | MERTK (0.68) | ACVRL1AXLMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456175-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114456176-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |