Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 17/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.64 |
| ▸ | SRC | P12931 | 16/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.64 |
| ▸ | EGFR | P00533 | 15/20 | 0.64 |
| ▸ | HCK | P08631 | 15/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.64 |
| ▸ | MTOR | P42345 | 15/20 | 0.64 |
| ▸ | EPHB4 | P54760 | 15/20 | 0.64 |
| ▸ | PRKDC | P78527 | 15/20 | 0.64 |
| ▸ | KDR | P35968 | 14/20 | 0.64 |
| ▸ | PI4KB | Q9UBF8 | 13/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130481 | 0.85 | PIK3CD (0.71) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL30387348 | 0.78 | ABL1 (1.00) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL28805803 | 0.78 | ABL1 (1.00) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL130598 | 0.77 | SRC (0.75) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL234181 | 0.75 | SRC (0.80) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL24458348 | 0.74 | RET (0.56) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL13019881 | 0.74 | CYP1A2 (0.67) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL15576326 | 0.74 | BTK (0.59) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL24458871 | 0.73 | RET (0.47) | ABL1PIK3CAPIK3CGSRCPIK3CD | |
| SCHEMBL24458853 | 0.73 | RET (0.47) | ABL1PIK3CAPIK3CGSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442783-B2 | 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442783-B2 | 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases | PIK3CB, PIK3CD, PDPK1 | ABL1 329/4885PIK3CA 4/4885PIK3CG 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.