SCHEMBL214681

SCHEMBL214681

C=NOCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.52
IDO1 P14902 1/20 0.48
AGXT P21549 1/20 0.46
RAB9A P51151 3/20 0.42
NPC1 O15118 2/20 0.42
ALDH1A1 P00352 3/20 0.40
CA1 P00915 3/20 0.40
CA2 P00918 3/20 0.40
CA9 Q16790 3/20 0.40
SLC6A2 P23975 2/20 0.40
SLC6A3 Q01959 2/20 0.40
LMNA P02545 1/20 0.40
CYP1A2 P05177 1/20 0.40
PTGS1 P23219 1/20 0.40
CYP2C19 P33261 1/20 0.40
PTGS2 P35354 1/20 0.40
HIF1A Q16665 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
CA7 P43166 1/20 0.39
CALM1 P0DP23 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27540563 0.91 CALM1 (0.50) TSHRIDO1AGXTRAB9ANPC1
SCHEMBL27576298 0.91 MAOA (0.45) TSHRIDO1AGXTALDH1A1MAOA
SCHEMBL14074966 0.87 IDO1 (0.55) TSHRIDO1AGXTRAB9ANPC1
Hydrochloric Acid SCHEMBL27547291 0.85 AGXT (0.57) TSHRIDO1AGXTRAB9ANPC1
SCHEMBL27479577 0.83 LTA4H (0.52) TSHRMAOA
SCHEMBL14075081 0.82 TSHR (0.56) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL14074970 0.82 AGXT (0.59) TSHRAGXTCYP2C19
Hydrochloric Acid SCHEMBL27479204 0.80 LCK (0.44) IDO1RAB9ANPC1CA9LMNA
SCHEMBL16005783 0.79 TSHR (0.57) TSHRIDO1AGXTRAB9ANPC1
SCHEMBL8600039 0.79 KMT2A (0.47) RAB9AALDH1A1LMNACYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114591197-A Process method for continuously synthesizing oxime ether 浙江圣安化工股份有限公司 2022-06-07 CN claimed
CN-106232567-A Propalane derivatives and synthesis 卡利拉制药公司 2016-12-14 CN claimed
CN-105814013-A Bicycloalkyl compounds and synthesis 卡利拉制药公司 2016-07-27 CN claimed
WO-2014141181-A1 PROCESS FOR PREPARING PEPTIDE DEFORMYLASE INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY NO 2 LIMITED (GB) 2014-09-18 WO claimed
US-20120077941-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2012-03-29 US claimed
US-8088868-B2 oximation of cojugated homopolymers formed by addtion polymerization of conjugated diene monomer in the presence lanthanide copmpounds as polymerization catalysts; polymers used in the manufacture of tires having reduced hysteresis BRIDGESTONE CORPORATION (JP) 2012-01-03 US claimed
US-20080293674-A1 Azinyl Imidazoazine and Azinyl Carboxamide BAYER CROPSCIENCE AG (DE) 2008-11-27 US claimed
US-20080146745-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2008-06-19 US claimed
EP-1751152-A2 AZINYL IMIDAZOAZINE AND AZINYL CARBOXAMIDE Bayer CropScience Aktiengesellschaft (DE) 2007-02-14 EP claimed
WO-2005113553-A2 AZINYL IMIDAZOAZINE AND AZINYL CARBOXAMIDE BAYER CROPSCIENCE AG (DE) 2005-12-01 WO claimed
EP-0377532-B1 THIOFORMAMIDE DERIVATIVES MAY AND BAKER LIMITED (GB) 1992-07-29 EP claimed
US-5104883-A Cardiovascular, respiratory, gastrointestirol, urogenital disorders; baldness; premature labor MAY & BAKER LIMITED (GB) 1992-04-14 US claimed
EP-0451168-A1 1-PHENYL-3-CARBOXYAMIDOPYRROLIDONES AND THEIR USE AS HERBICIDES. ICI AMERICA INC (US) 1991-10-16 EP claimed
WO-1990007500-A1 1-PHENYL-3-CARBOXYAMIDOPYRROLIDONES AND THEIR USE AS HERBICIDES ICI AMERICAS INC. (US) 1990-07-12 WO claimed
EP-0377532-A1 Thioformamide derivatives MAY AND BAKER LIMITED (GB) 1990-07-11 EP claimed
US-4913722-A HERBICIDES ICI AMERICAS INC. (US) 1990-04-03 US claimed
US-4877880-A REACTING AN N-3-SUBSTITUTED ALLYL ANILINE WITH AN ARYLISOTHIOCYANATE, REACTING THE RESULTANT THIOUREA WITH A (TRIFLUORO-)METHANESULFONIC ACID ICI AMERICAS INC. (US) 1989-10-31 US claimed
US-4874422-A 1-Phenyl-3-carboxyamidopyrrolidones and their use as herbicides ICI AMERICAS INC. (US) 1989-10-17 US claimed
EP-0318253-A1 Iminophenylthiazolidines, process of preparation, and method of use ICI AMERICAS INC. (US) 1989-05-31 EP claimed
US-4576753-A MICROBIOCIDES, ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1986-03-18 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080293674-A1 Azinyl Imidazoazine and Azinyl Carboxamide AZI2, NISCH, ZYX TSHR 3493/4885IDO1 93/4885AGXT 2744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.