Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 3/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | NR2C2 | P49116 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.42 |
| ▸ | CSK | P41240 | 3/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21470715 | 0.96 | KIT (0.45) | HCKBTKKITABL1RET | |
| SCHEMBL21470839 | 0.95 | KIT (0.43) | HCKBTKNR2C2KITEPHA2 | |
| SCHEMBL21470534 | 0.89 | HCK (0.44) | HCKBTKNR2C2KITMAP3K7 | |
| SCHEMBL21471041 | 0.89 | SRC (0.51) | KITMKNK2MKNK1ABL1RET | |
| SCHEMBL21470533 | 0.89 | KIT (0.44) | KITABL1KDRSRCCSF1R | |
| SCHEMBL21471038 | 0.88 | KIT (0.47) | KITABL1RETSRCBCR | |
| SCHEMBL21470718 | 0.88 | KIT (0.40) | HCKBTKNR2C2KITDDR1 | |
| SCHEMBL21471075 | 0.88 | HCK (0.44) | HCKBTKNR2C2KITMAP3K7 | |
| SCHEMBL21471042 | 0.87 | RET (0.49) | KITMKNK2MKNK1ABL1RET | |
| SCHEMBL23353703 | 0.87 | ABL1 (0.43) | HCKBTKKITMKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139484-A1 | DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | GOSSAMER BIO SERVICES INC (US) | 2021-05-13 | — | — | US | disclosed |
| WO-2019200120-A1 | DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | LYCERA CORPORATION (US) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139484-A1 | DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | ULK1, PHKG2, PHKG1 | HCK 146/4885BTK 2085/4885NR2C2 728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.