Sugi Predict

Sugi Predict / Compounds / SCHEMBL2147182

SCHEMBL2147182

SCHEMBL2147182

COC(=O)c1nnc(NC(C)=O)[nH]1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.37
▸ ALDH1A1 P00352 4/20 0.36
▸ HSD17B10 Q99714 3/20 0.36
▸ CYP1A2 P05177 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ MAPT P10636 3/20 0.35
▸ F2 P00734 2/20 0.35
▸ NPSR1 Q6W5P4 2/20 0.34
▸ SMN1; SMN2 Q16637 4/20 0.33
▸ HPGD P15428 2/20 0.33
▸ GDA Q9Y2T3 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ ADORA3 P0DMS8 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22165408 0.78 ATR (0.41) LMNAALDH1A1HSD17B10KMT2AMAPT
SCHEMBL12824342 0.76 LMNA (0.31) LMNA
SCHEMBL21547810 0.72 NPSR1 (0.39) LMNAALDH1A1HSD17B10CYP1A2KMT2A
SCHEMBL12460577 0.72 NPSR1 (0.39) LMNAALDH1A1HSD17B10CYP1A2KMT2A
SCHEMBL23063364 0.71 NPSR1 (0.38) LMNAALDH1A1HSD17B10CYP1A2KMT2A
SCHEMBL2147001 0.71 NPSR1 (0.38) LMNAALDH1A1HSD17B10CYP1A2KMT2A
SCHEMBL8627227 0.71 LMNA (0.40) LMNAALDH1A1HSD17B10SMN1; SMN2GDA
SCHEMBL15132948 0.70 LMNA (0.32) LMNA
Hydrochloric Acid SCHEMBL25427971 0.69 TSHR (0.38) LMNAALDH1A1HSD17B10CYP1A2KMT2A
SCHEMBL21538964 0.68 ALDH1A1 (0.40) LMNAALDH1A1HSD17B10CYP1A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9227971-B2 Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors MERCK SHARP & DOHME CORP. (US) 2016-01-05 — — US disclosed
US-9227971-B2 Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors MERCK SHARP & DOHME CORP. (US) 2016-01-05 — — US disclosed
US-20120322791-A1 PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS MERCK SHARP & DOHME LLC 2012-12-20 — — US disclosed
US-20120322791-A1 PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS MERCK SHARP & DOHME LLC 2012-12-20 — — US disclosed
WO-2011090935-A1 PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS MERCK SHARP & DOHME CORP. (US) 2011-07-28 — — WO disclosed
WO-2011090935-A1 PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS MERCK SHARP & DOHME CORP. (US) 2011-07-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120322791-A1 PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS MTOR, RICTOR, RPS6KA5 LMNA 4194/4885ALDH1A1 2634/4885HSD17B10 4456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.