Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | XIAP | P98170 | 1/20 | 0.81 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.81 |
| ▸ | THRB | P10828 | 5/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17357512 | 1.00 | ALOX15 (0.81) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL18360796 | 0.89 | ALOX15 (1.00) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL17357510 | 0.89 | ALOX15 (1.00) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL31278555 | 0.89 | ALOX15 (1.00) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL7741515 | 0.89 | ALOX15 (1.00) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL7746346 | 0.87 | ALOX15 (0.78) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL22997082 | 0.86 | ALOX15 (0.69) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL18360794 | 0.86 | KDM4E (0.72) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL23706154 | 0.86 | KDM4E (0.72) | ALOX15KDM4EALDH1A1TSHRXIAP | |
| SCHEMBL21473669 | 0.86 | THRB (0.79) | ALOX15KDM4EALDH1A1TSHRXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019196938-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | 华东理工大学 | 2019-10-17 | — | — | WO | disclosed |