Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22997449 | 0.86 | MEN1 (0.59) | MEN1KMT2AMAPTTDP1ALOX15 | |
| SCHEMBL6289218 | 0.78 | TP53 (0.60) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL6287582 | 0.78 | TP53 (0.60) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL4856275 | 0.78 | TP53 (0.60) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL29419401 | 0.77 | MEN1 (0.73) | MEN1KMT2AMAPTTDP1ALOX15 | |
| SCHEMBL30046742 | 0.77 | ALOX15 (0.59) | MEN1KMT2AMAPTTDP1ALOX15 | |
| SCHEMBL21473668 | 0.76 | THRB (0.61) | MAPTTDP1ALOX15KDM4EALDH1A1 | |
| SCHEMBL23424735 | 0.75 | ALOX15 (0.45) | MEN1KMT2AMAPTTDP1ALOX15 | |
| SCHEMBL27679834 | 0.74 | SLC6A2 (0.60) | MAPTTP53THRB | |
| SCHEMBL23424771 | 0.74 | THRB (0.57) | MAPTTDP1ALOX15KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019196938-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | 华东理工大学 | 2019-10-17 | — | — | WO | disclosed |