Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8462360 | 1.00 | TSHR (0.62) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL11777806 | 0.96 | MEN1 (0.59) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL3348481 | 0.88 | MEN1 (0.59) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL11632540 | 0.88 | MEN1 (0.49) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL343011 | 0.86 | MAPT (0.77) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL28692016 | 0.85 | MEN1 (0.56) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL27411599 | 0.85 | MEN1 (0.60) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL4776752 | 0.85 | KMT2A (0.56) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL28924092 | 0.84 | ALDH1A1 (0.53) | TSHRTP53MEN1KMT2AMAPT | |
| SCHEMBL11630201 | 0.84 | ALDH1A1 (0.53) | TSHRTP53MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280701-B1 | A METHOD OF CHIRAL RESOLUTION OF THE KEY INTERMEDIATE OF THE SYNTHESIS OF APREMILAST AND ITS USE FOR THE PREPARATION OF PURE APREMILAST | ZENTIVA KS (CZ) | 2019-10-16 | — | — | EP | disclosed |