Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405889 | 0.87 | HCAR3 (0.45) | POLBKDM4EMAP4K1MEN1LMNA | |
| SCHEMBL24405980 | 0.82 | PGR (0.43) | ALDH1A1KDM4EMAP4K1TSHRLMNA | |
| SCHEMBL21474172 | 0.80 | PTK2 (0.44) | ALDH1A1KDM4EGAAMAP4K1TSHR | |
| SCHEMBL23119775 | 0.80 | HSD17B10 (0.46) | POLBALDH1A1MAP4K1TSHRLMNA | |
| SCHEMBL29581561 | 0.77 | AURKA (0.46) | MAPK8MAP4K1LMNAHSP90AA1MAPT | |
| SCHEMBL27261699 | 0.77 | HCAR3 (0.46) | POLBMAP4K1MEN1KMT2APIK3CA | |
| SCHEMBL24405682 | 0.77 | PGR (0.36) | MAP4K1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27253472 | 0.77 | PCSK9 (0.33) | MAP4K1PIK3CAPRKDCGSK3BMTOR | |
| SCHEMBL29311983 | 0.77 | PCSK9 (0.33) | MAP4K1PIK3CAPRKDCGSK3BMTOR | |
| SCHEMBL21474179 | 0.76 | GAA (0.39) | ALDH1A1GAATSHRMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019198692-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC. (JP) | 2019-10-17 | — | — | WO | disclosed |