SCHEMBL21474573

SCHEMBL21474573

CCOC(=O)C1=C(Sc2ccccc2)c2cc(Cl)ccc2CC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
HPGD P15428 4/20 0.41
KDM4E B2RXH2 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
TUBB4A P04350 2/20 0.41
TUBB P07437 2/20 0.41
TUBA3C P0DPH7 2/20 0.41
TUBA1B P68363 2/20 0.41
TUBA4A P68366 2/20 0.41
TUBB4B P68371 2/20 0.41
TUBB3 Q13509 2/20 0.41
TUBB2A Q13885 2/20 0.41
TUBB8 Q3ZCM7 2/20 0.41
TUBA3E Q6PEY2 2/20 0.41
TUBA1A Q71U36 2/20 0.41
TUBA1C Q9BQE3 2/20 0.41
TUBB6 Q9BUF5 2/20 0.41
TUBB2B Q9BVA1 2/20 0.41
TUBB1 Q9H4B7 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21474579 0.92 HRH1 (0.42) ALDH1A1HPGDKDM4EL3MBTL1TDP1
SCHEMBL21474668 0.91 POLB (0.39) ALDH1A1HPGDKDM4EL3MBTL1TDP1
SCHEMBL21474575 0.88 ALDH1A1 (0.41) ALDH1A1HPGDKDM4EL3MBTL1TDP1
SCHEMBL21474672 0.87 MAPK14 (0.42) ALDH1A1HPGDKDM4EL3MBTL1TDP1
SCHEMBL21474555 0.85 ALDH1A1 (0.40) ALDH1A1HPGDKDM4EL3MBTL1TDP1
SCHEMBL21478248 0.81 MAPT (0.40) ALDH1A1HPGDTUBB4ATUBBTUBA3C
SCHEMBL21478257 0.79 ALDH1A1 (0.49) ALDH1A1HPGDKDM4EL3MBTL1TDP1
SCHEMBL25549318 0.78 KDM4E (0.45) ALDH1A1HPGDKDM4EL3MBTL1TDP1
SCHEMBL21474571 0.74 MAPK1 (0.42) ALDH1A1HPGDTUBB4ATUBBTUBA3C
SCHEMBL15679173 0.72 CYP1A2 (0.49) ALDH1A1HPGDCYP2C19CYP1A2XBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019199979-A1 ANTIBACTERIAL COMPOUNDS THE GENERAL HOSPITAL CORPORATION (US) 2019-10-17 WO disclosed