SCHEMBL21474634

SCHEMBL21474634

Cc1ccc(C)c2oc(-c3ccncc3)nc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARA P10276 4/20 0.46
RARB P10826 4/20 0.46
RARG P13631 4/20 0.46
TP53 P04637 2/20 0.44
PKM P14618 1/20 0.44
NPC1 O15118 5/20 0.41
RAB9A P51151 5/20 0.41
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
S1PR1 P21453 1/20 0.39
GAA P10253 2/20 0.39
HSD17B10 Q99714 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
STAT1 P42224 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ATAD2 Q6PL18 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18873093 0.84 RARA (0.50) RARARARBRARGNPC1RAB9A
SCHEMBL17059011 0.84 RARA (0.50) RARARARBRARGTP53NPC1
SCHEMBL21474854 0.80 RAB9A (0.50) TP53NPC1RAB9AMEN1KMT2A
SCHEMBL21474855 0.78 RARA (0.46) RARARARBRARGRAB9AMEN1
SCHEMBL14266187 0.76 CETP (0.47) TP53PKMNPC1RAB9AGAA
SCHEMBL10126037 0.74 TDP1 (0.46) RARARARBRARGNPC1RAB9A
SCHEMBL13621028 0.74 RARA (0.46) RARARARBRARGNPC1RAB9A
SCHEMBL12689381 0.73 PIK3CB (0.44) TP53PKMNPC1RAB9AMEN1
SCHEMBL4544449 0.73 PIK3CB (0.44) TP53PKMNPC1RAB9AMEN1
SCHEMBL10125872 0.72 TDP1 (0.51) RARARARBRARGNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200115482-A1 MIXTURE, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC PRODUCT, POLARIZING PLATE, DISPLAY DEVICE, ANTIREFLECTION FILM, AND PRODUCTION METHOD FOR MIXTURE ZEON CORPORATION (JP) 2020-04-16 US disclosed
US-20200031971-A1 MIXTURE, POLYMERIZABLE COMPOSITION, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC PRODUCT, POLARIZING PLATE, FLAT PANEL DISPLAY DEVICE, ORGANIC ELECTROLUMINESCENT DISPLAY DEVICE, ANTIREFLECTION FILM, AND METHOD OF USING POLYMERIZABLE COMPOUND ZEON CORPORATION (JP) 2020-01-30 US disclosed
US-20190330399-A1 POLYMERIZABLE COMPOUND, MIXTURE, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC BODY, POLARIZER, DISPLAY, AND ANTIREFLECTION FILM ZEON CORPORATION (JP) 2019-10-31 US disclosed
US-20190315893-A1 POLYMERIZABLE COMPOUND, MIXTURE, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC PRODUCT, POLARIZING PLATE, DISPLAY DEVICE, AND ANTIREFLECTION FILM ZEON CORPORATION (JP) 2019-10-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190315893-A1 POLYMERIZABLE COMPOUND, MIXTURE, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC PRODUCT, POLARIZING PLATE, DISPLAY DEVICE, AND ANTIREFLECTION FILM CCNA1, CCNA2, ADRA1A RARA 312/4885RARB 978/4885RARG 951/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.