Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21476169 | 0.85 | CREBBP (0.35) | CREBBPDYRK1APTGS2PRMT5WDR77 | |
| SCHEMBL21484163 | 0.83 | SIGMAR1 (0.33) | SIGMAR1SLC6A4SLC6A3CREBBPPTGS2 | |
| SCHEMBL22757231 | 0.83 | PTGS2 (0.38) | SIGMAR1PTGS2 | |
| SCHEMBL22757285 | 0.80 | PTGS2 (0.36) | SIGMAR1PTGS2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL21476167 | 0.79 | SLC6A4 (0.39) | SIGMAR1SLC6A4SLC6A3CREBBPDYRK1A | |
| SCHEMBL21459527 | 0.79 | HRH3 (0.48) | DYRK1ATAAR1 | |
| SCHEMBL16118977 | 0.70 | MGLL (0.44) | CREBBPALDH1A1CYP3A4 | |
| SCHEMBL9494291 | 0.69 | CREBBP (0.40) | CREBBPDYRK1APRMT5WDR77 | |
| SCHEMBL18306497 | 0.69 | BRD4 (0.49) | CREBBPDYRK1ATAAR1ALDH1A1 | |
| SCHEMBL21476163 | 0.68 | PTGS2 (0.40) | PTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200202-A1 | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7) | MORPHIC THERAPEUTIC, INC. (US) | 2019-10-17 | — | — | WO | disclosed |