Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.49 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22300036 | 1.00 | MAOA (0.49) | MAOAMAOBCES1TGM2AGTR1 | |
| SCHEMBL15764198 | 0.93 | TGM2 (0.50) | MAOAMAOBCES1TGM2AGTR1 | |
| SCHEMBL23752448 | 0.90 | TGM2 (0.61) | MAOAMAOBCES1TGM2AGTR1 | |
| SCHEMBL12589678 | 0.90 | TGM2 (0.57) | MAOAMAOBCES1TGM2AGTR1 | |
| SCHEMBL3848773 | 0.90 | TGM2 (0.61) | MAOAMAOBCES1TGM2AGTR1 | |
| Indirubin SCHEMBL20535353 | 0.86 | MAOA (0.64) | MAOAMAOBTGM2NTRK1CCNA2 | |
| Indirubin SCHEMBL9899338 | 0.86 | MAOA (0.64) | MAOAMAOBTGM2NTRK1CCNA2 | |
| Indirubin SCHEMBL27678 | 0.86 | MAOA (0.64) | MAOAMAOBTGM2NTRK1CCNA2 | |
| Indirubin SCHEMBL6809175 | 0.86 | MAOA (0.64) | MAOAMAOBTGM2NTRK1CCNA2 | |
| Indirubin SCHEMBL31032717 | 0.86 | MAOA (0.64) | MAOAMAOBTGM2NTRK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524937-B2 | Indirubin derivatives, and uses thereof | CITY OF HOPE (US) | 2022-12-13 | — | — | US | disclosed |
| US-11220491-B2 | Photoprotective compositions containing Malassezia-derived compounds and/or chemical analogs thereof | VERSICOLOR TECHNOLOGIES, LLC (US) | 2022-01-11 | — | — | US | disclosed |
| US-11202748-B2 | Photoprotective compositions containing malassezia-derived compounds and/or chemical analogs thereof | VERSICOLOR TECHNOLOGIES, LLC (US) | 2021-12-21 | — | — | US | disclosed |
| US-20200276100-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | VERSICOLOR TECHNOLOGIES, LLC | 2020-09-03 | — | — | US | disclosed |
| US-20200247750-A1 | INDIRUBIN DERIVATIVES, AND USES THEREOF | CITY OF HOPE | 2020-08-06 | — | — | US | disclosed |
| US-20200060952-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | VERSICOLOR TECHNOLOGIES, LLC | 2020-02-27 | — | — | US | disclosed |
| US-20190345140-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | VERSICOLOR TECHNOLOGIES, LLC | 2019-11-14 | — | — | US | disclosed |
| WO-2019217387-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | EINZIGER MICHAEL (US) | 2019-11-14 | — | — | WO | disclosed |
| US-20190337927-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | VERSICOLOR TECHNOLOGIES, LLC | 2019-11-07 | — | — | US | disclosed |
| WO-2019200232-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | EINZIGER MICHAEL (US) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524937-B2 | Indirubin derivatives, and uses thereof | HCCS, ABL1, MAP3K7 | MAOA 2340/4885MAOB 1244/4885CES1 3870/4885 |
| US-20190337927-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | TYR, AHR, MC1R | MAOA 383/4885MAOB 234/4885CES1 3567/4885 |
| US-11202748-B2 | Photoprotective compositions containing malassezia-derived compounds and/or chemical analogs thereof | TYR, AHR, MC1R | MAOA 626/4885MAOB 505/4885CES1 2985/4885 |
| US-20190345140-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | TYR, AHR, MC1R | MAOA 626/4885MAOB 505/4885CES1 2985/4885 |
| US-20200276100-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | TYR, AHR, MC1R | MAOA 420/4885MAOB 560/4885CES1 2459/4885 |
| US-20200247750-A1 | INDIRUBIN DERIVATIVES, AND USES THEREOF | HCCS, ABL1, MAP3K7 | MAOA 2340/4885MAOB 1244/4885CES1 3870/4885 |
| US-20200060952-A1 | PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF | TYR, AHR, MC1R | MAOA 626/4885MAOB 505/4885CES1 2985/4885 |
| US-11220491-B2 | Photoprotective compositions containing Malassezia-derived compounds and/or chemical analogs thereof | TYR, AHR, MC1R | MAOA 626/4885MAOB 505/4885CES1 2985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.