Sugi Predict

Sugi Predict / Compounds / SCHEMBL21480103

SCHEMBL21480103

SCHEMBL21480103

O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2C1=O

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 2/20 0.50
▸ MAOB P27338 2/20 0.50
▸ FLT3 P36888 3/20 0.48
▸ LRRK2 Q5S007 4/20 0.46
▸ KMT2A Q03164 2/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ AGTR1 P30556 1/20 0.44
▸ KDR P35968 1/20 0.44
▸ CA1 P00915 3/20 0.44
▸ CA2 P00918 3/20 0.44
▸ PDGFRA P16234 1/20 0.42
▸ FER P16591 1/20 0.42
▸ LTK P29376 1/20 0.42
▸ CDK8 P49336 1/20 0.42
▸ ACVR1 Q04771 1/20 0.42
▸ DYRK1B Q9Y463 1/20 0.42
▸ RPS6KA3 P51812 1/20 0.41
▸ EGFR P00533 2/20 0.40
▸ PIM1 P11309 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3848509 1.00 MAOA (0.50) MAOAMAOBFLT3LRRK2KMT2A
SCHEMBL16583648 0.94 FLT3 (0.48) MAOAMAOBFLT3LRRK2KMT2A
SCHEMBL11890574 0.86 FLT3 (0.54) MAOAMAOBFLT3LRRK2KMT2A
SCHEMBL11029136 0.86 FLT3 (0.54) MAOAMAOBFLT3LRRK2KMT2A
Indirubin SCHEMBL31032717 0.84 MAOA (0.64) MAOAMAOBLRRK2KMT2AMEN1
Indirubin SCHEMBL20535353 0.84 MAOA (0.64) MAOAMAOBLRRK2KMT2AMEN1
Indirubin SCHEMBL9899338 0.84 MAOA (0.64) MAOAMAOBLRRK2KMT2AMEN1
Indirubin SCHEMBL6809175 0.84 MAOA (0.64) MAOAMAOBLRRK2KMT2AMEN1
Indirubin SCHEMBL29361016 0.84 MAOA (0.64) MAOAMAOBLRRK2KMT2AMEN1
Indirubin SCHEMBL27678 0.84 MAOA (0.64) MAOAMAOBLRRK2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240010635-A1 NOVEL INDIRUBIN DERIVATIVES HAVING HETEROBICYCLIC MOIETIES AND THE USE THEREOF Pelemed Co., Ltd. (KR) 2024-01-11 — — US disclosed
EP-4253385-A1 NOVEL INDIRUBIN DERIVATIVE HAVING HETEROBICYCLIC RESIDUE AND USE THEREOF Pelemed Co., Ltd. (KR) 2023-10-04 — — EP disclosed
WO-2023153630-A1 NOVEL INDIRUBIN DERIVATIVE HAVING HETEROBICYCLIC RESIDUE AND USE THEREOF 주식회사 펠레메드 2023-08-17 — — WO disclosed
US-11220491-B2 Photoprotective compositions containing Malassezia-derived compounds and/or chemical analogs thereof VERSICOLOR TECHNOLOGIES, LLC (US) 2022-01-11 — — US disclosed
US-11202748-B2 Photoprotective compositions containing malassezia-derived compounds and/or chemical analogs thereof VERSICOLOR TECHNOLOGIES, LLC (US) 2021-12-21 — — US disclosed
US-20200276100-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF VERSICOLOR TECHNOLOGIES, LLC 2020-09-03 — — US disclosed
US-20200060952-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF VERSICOLOR TECHNOLOGIES, LLC 2020-02-27 — — US disclosed
US-20190345140-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF VERSICOLOR TECHNOLOGIES, LLC 2019-11-14 — — US disclosed
WO-2019217387-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF EINZIGER MICHAEL (US) 2019-11-14 — — WO disclosed
US-20190337927-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF VERSICOLOR TECHNOLOGIES, LLC 2019-11-07 — — US disclosed
WO-2019200232-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF EINZIGER MICHAEL (US) 2019-10-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190337927-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF TYR, AHR, MC1R MAOA 383/4885MAOB 234/4885FLT3 3508/4885
US-11202748-B2 Photoprotective compositions containing malassezia-derived compounds and/or chemical analogs thereof TYR, AHR, MC1R MAOA 626/4885MAOB 505/4885FLT3 3462/4885
US-20190345140-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF TYR, AHR, MC1R MAOA 626/4885MAOB 505/4885FLT3 3462/4885
US-20200276100-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF TYR, AHR, MC1R MAOA 420/4885MAOB 560/4885FLT3 2837/4885
US-20200060952-A1 PHOTOPROTECTIVE COMPOSITIONS CONTAINING MALASSEZIA-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF TYR, AHR, MC1R MAOA 626/4885MAOB 505/4885FLT3 3462/4885
US-20240010635-A1 NOVEL INDIRUBIN DERIVATIVES HAVING HETEROBICYCLIC MOIETIES AND THE USE THEREOF FLT3, RET, FER MAOA 2977/4885MAOB 1138/4885FLT3 1/4885
US-11220491-B2 Photoprotective compositions containing Malassezia-derived compounds and/or chemical analogs thereof TYR, AHR, MC1R MAOA 626/4885MAOB 505/4885FLT3 3462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.