SCHEMBL21484540

SCHEMBL21484540

O=C(O)c1cc(Cl)cc(S(=O)(=O)C(F)(F)F)c1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TPMT P51580 1/20 0.53
HCAR1 Q9BXC0 1/20 0.47
LCK P06239 1/20 0.44
FYN P06241 1/20 0.44
EPAS1 Q99814 6/20 0.44
ACLY P53396 2/20 0.43
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
WDR5 P61964 1/20 0.40
CYP1A2 P05177 1/20 0.40
HCAR2 Q8TDS4 1/20 0.38
TTR P02766 1/20 0.37
RXRA P19793 1/20 0.37
RXRB P28702 1/20 0.37
P2RX1 P51575 1/20 0.36
ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL732949 0.87 LCK (0.57) TPMTHCAR1LCKFYNEPAS1
SCHEMBL18513400 0.87 LCK (0.52) TPMTHCAR1LCKFYNEPAS1
SCHEMBL21609775 0.81 CES2 (0.47) LCKFYNMEN1KMT2ACYP1A2
SCHEMBL29482054 0.81 CES2 (0.47) LCKFYNMEN1KMT2ACYP1A2
SCHEMBL23411175 0.79 LCK (0.44) LCKFYNEPAS1ACLYMEN1
SCHEMBL11821992 0.79 LCK (0.44) TPMTHCAR1LCKFYNEPAS1
SCHEMBL29728960 0.79 LCK (0.44) LCKFYNEPAS1ACLYMEN1
SCHEMBL18503859 0.79 LCK (0.44) TPMTLCKFYNEPAS1MEN1
SCHEMBL11818964 0.79 LCK (0.44) TPMTHCAR1LCKFYNEPAS1
SCHEMBL9040490 0.78 TPMT (0.61) TPMTHCAR1LCKFYNACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250042875-A1 PESTICIDALLY ACTIVE PYRIDAZINONE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2025-02-06 US disclosed
EP-4423077-A1 PESTICIDALLY ACTIVE PYRIDAZINONE COMPOUNDS Syngenta Crop Protection AG (CH) 2024-09-04 EP disclosed
CN-118265707-A Pesticidally active pyridazinone compounds 先正达农作物保护股份公司 2024-06-28 CN disclosed
CN-116969925-A Heteroaryl-triazole compounds 拜耳公司 2023-10-31 CN disclosed
CN-116925043-A Heteroaryl-triazole compounds 拜耳公司 2023-10-24 CN disclosed
EP-3904350-B1 N-(CYCLOPROPYLMETHYL)-5-(METHYLSULFONYL)-N-{1-[1-(PYRIMIDIN-2-YL)-1H-1,2,4-TRIAZOL-5-YL]ETHYL}BENZAMIDE DERIVATIVES AND THE CORRESPONDING PYRIDINE-CARBOXAMIDE DERIVATIVES AS PESTICIDES BAYER AG (DE) 2023-08-23 EP disclosed
EP-3904349-B1 N-(CYCLOPROPYLMETHYL)-5-(METHYLSULFONYL)-N-{1-[1-(PYRIMIDIN-2-YL)-1H-1,2,4-TRIAZOL-5-YL]ETHYL}HETEROCYCLYL AMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS PESTICIDES BAYER AG (DE) 2023-08-23 EP disclosed
WO-2023072849-A1 PESTICIDALLY ACTIVE PYRIDAZINONE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-05-04 WO disclosed
EP-3774778-B1 N-(CYCLOPROPYLMETHYL)-5-(METHYLSULFONYL)-N-{1-[1-(PYRIMIDIN-2-YL)-1H-1,2,4-TRIAZOL-5-YL]ETHYL}BENZAMIDE DERIVATIVES AND THE CORRESPONDING PYRIDINE-CARBOXAMIDE DERIVATIVES AS PESTICIDES BAYER AG (DE) 2023-01-18 EP disclosed
EP-3904349-A2 N-(CYCLOPROPYLMETHYL)-5-(METHYLSULFONYL)-N-{1-[1-(PYRIMIDIN-2-YL)-1H-1,2,4-TRIAZOL-5-YL]ETHYL}HETEROCYCLYL AMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS PESTICIDES Bayer Aktiengesellschaft (DE) 2021-11-03 EP disclosed
EP-3904350-A1 N-(CYCLOPROPYLMETHYL)-5-(METHYLSULFONYL)-N-{1-[1-(PYRIMIDIN-2-YL)-1H-1,2,4-TRIAZOL-5-YL]ETHYL}BENZAMIDE DERIVATIVES AND THE CORRESPONDING PYRIDINE-CARBOXAMIDE DERIVATIVES AS PESTICIDES Bayer Aktiengesellschaft (DE) 2021-11-03 EP disclosed
US-20210147387-A1 NOVEL HETEROARYL-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2021-05-20 US disclosed
WO-2019197468-A1 N-(CYCLOPROPYLMETHYL)-5-(METHYLSULFONYL)-N-{1-[1-(PYRIMIDIN-2-YL)-1H-1,2,4-TRIAZOL-5-YL]ETHYL}BENZAMIDE DERIVATIVES AND THE CORRESPONDING PYRIDINE-CARBOXAMIDE DERIVATIVES AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2019-10-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210147387-A1 NOVEL HETEROARYL-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS AS PESTICIDES CYP4F3, TARS2, H1-3 TPMT 4215/4885HCAR1 2222/4885LCK 3505/4885
US-20250042875-A1 PESTICIDALLY ACTIVE PYRIDAZINONE COMPOUNDS ACHE, PNPO, DDT TPMT 1057/4885HCAR1 4632/4885LCK 981/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.