Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.56 |
| ▸ | YAP1 | P46937 | 1/20 | 0.56 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.56 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 4/20 | 0.47 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11437199 | 0.83 | EPHX1 (0.50) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL9639726 | 0.79 | MAPT (0.55) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL20725799 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL1503954 | 0.76 | NPC1 (0.66) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL16922181 | 0.76 | NPC1 (0.66) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL8006944 | 0.76 | MEN1 (0.72) | MEN1KMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5574769 | 0.76 | LMNA (0.66) | TEAD1YAP1TEAD4TEAD2MEN1 | |
| SCHEMBL14620842 | 0.74 | GRIN1 (0.47) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL1947326 | 0.73 | MEN1 (0.47) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL2296216 | 0.73 | FFAR1 (0.60) | MEN1KMT2AALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3552664-A1 | PROTEOSTASIS REGULATORS | Proteostasis Therapeutics, Inc. (US) | 2019-10-16 | — | — | EP | disclosed |