Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20725809 | 0.86 | ALDH1A1 (0.67) | ALDH1A1HPGDGAAKDM4ETHRB | |
| SCHEMBL21484730 | 0.78 | TEAD1 (0.56) | ALDH1A1CNR1GAASMN1; SMN2NPC1 | |
| SCHEMBL9615508 | 0.77 | L3MBTL1 (0.62) | ALDH1A1HPGDGAASMN1; SMN2NPC1 | |
| SCHEMBL10891769 | 0.73 | CNR1 (0.59) | ALDH1A1CNR1GAASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL29531112 | 0.73 | CNR1 (0.59) | ALDH1A1CNR1GAASMN1; SMN2KDM4E | |
| SCHEMBL9372120 | 0.71 | KMT2A (0.42) | ALDH1A1CNR1GAASMN1; SMN2NPC1 | |
| SCHEMBL9639726 | 0.70 | MAPT (0.55) | ALDH1A1HPGDGAANPC1MAPT | |
| SCHEMBL22834152 | 0.70 | CNR1 (1.00) | ALDH1A1CNR1SMN1; SMN2MAPTLMNA | |
| SCHEMBL22407656 | 0.69 | KDM4E (0.63) | ALDH1A1HPGDGAAKDM4ETHRB | |
| SCHEMBL22407647 | 0.69 | KDM4E (0.63) | ALDH1A1HPGDGAAKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3552664-A1 | PROTEOSTASIS REGULATORS | Proteostasis Therapeutics, Inc. (US) | 2019-10-16 | — | — | EP | disclosed |
| EP-2707101-B1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS INC (US) | 2019-02-13 | — | — | EP | disclosed |