Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15231111 | 0.97 | NPC1 (0.60) | NPC1RAB9AALDH1A1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL15230826 | 0.96 | NPC1 (0.59) | NPC1RAB9AALDH1A1MAPTLMNA | |
| Hypochlorous Acid SCHEMBL21486160 | 0.87 | RAB9A (0.56) | NPC1RAB9AALDH1A1MAPTLMNA | |
| Hypochlorous Acid SCHEMBL21486121 | 0.84 | ALDH1A1 (0.55) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL15230313 | 0.84 | RAB9A (0.59) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL15230094 | 0.84 | NPC1 (0.48) | NPC1RAB9AALDH1A1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL15230096 | 0.83 | RAB9A (0.58) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL15066170 | 0.82 | NPC1 (0.65) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL30708218 | 0.82 | NPC1 (0.65) | NPC1RAB9AALDH1A1MAPTLMNA | |
| Hypochlorous Acid SCHEMBL21486014 | 0.81 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2819519-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2019-10-23 | — | — | EP | claimed |