Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148732 | 1.00 | LMNA (0.53) | LMNAMEN1KMT2ASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL2146359 | 0.99 | LMNA (0.52) | LMNAMEN1KMT2ASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL2146368 | 0.99 | LMNA (0.52) | LMNAMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL2146806 | 0.92 | ALDH1A1 (0.55) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL3021250 | 0.92 | LMNA (0.56) | LMNAMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL2146803 | 0.92 | ALDH1A1 (0.55) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL2146376 | 0.86 | SMN1; SMN2 (0.57) | LMNAMEN1KMT2ASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL2145809 | 0.85 | SMN1; SMN2 (0.56) | LMNAMEN1KMT2ASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL2145807 | 0.85 | SMN1; SMN2 (0.56) | LMNAMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL24323696 | 0.84 | ALDH1A1 (0.56) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |