SCHEMBL214885

SCHEMBL214885

NC(=O)CNc1cccc(O)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.57
KMT2A Q03164 2/20 0.50
ALDH1A1 P00352 2/20 0.50
CYP1A2 P05177 1/20 0.50
MEN1 O00255 1/20 0.47
KDM4E B2RXH2 1/20 0.46
PARP1 P09874 1/20 0.46
CYP3A4 P08684 1/20 0.46
TSHR P16473 1/20 0.46
HPGDS O60760 1/20 0.44
AKR1C3 P42330 1/20 0.44
NLRP3 Q96P20 3/20 0.43
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
MAPK1 P28482 1/20 0.42
RAB9A P51151 1/20 0.42
HIF1A Q16665 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
MMP1 P03956 1/20 0.41
MMP2 P08253 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6006586 0.87 SYK (0.48) SYKKMT2AALDH1A1CYP1A2MEN1
SCHEMBL6387979 0.83 TSHR (0.49) SYKKMT2AALDH1A1CYP1A2MEN1
Hydrochloric Acid SCHEMBL11309314 0.83 CYP3A4 (0.52) KMT2AALDH1A1CYP1A2MEN1CYP3A4
SCHEMBL150832 0.83 CYP3A4 (0.52) KMT2AALDH1A1CYP1A2MEN1CYP3A4
SCHEMBL21834459 0.82 ALDH1A1 (0.51) SYKKMT2AALDH1A1CYP1A2MEN1
SCHEMBL17560624 0.81 DDX3X (0.56) SYKKMT2AALDH1A1MEN1KDM4E
SCHEMBL966007 0.80 MAPT (0.58) SYKKMT2AALDH1A1CYP1A2MEN1
SCHEMBL4312818 0.80 MEN1 (0.56) SYKKMT2AALDH1A1MEN1KDM4E
SCHEMBL6322533 0.80 MEN1 (0.55) KMT2AALDH1A1MEN1KDM4EPARP1
SCHEMBL6904254 0.79 ALDH1A1 (0.51) SYKKMT2AALDH1A1CYP1A2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4785024-B2 2011-10-05 JP claimed
EP-1494995-B1 3-AMINOPHENOL DERIVATIVES SUBSTITUTED IN THE 2-POSITION, AND DYES CONTAINING THESE COMPOUNDS PROCTER & GAMBLE (US) 2010-09-22 EP claimed
US-RE41549-E1 Dyes for keratin fibers, the dyes containing n-benzyl-p-phenylenediamine derivatives and novel n-benzyl-p-phenylenediamine derivatives WELLA AG (DE) 2010-08-24 US claimed
CN-100549003-C 3-aminophenol derivatives and keratin fibre colorants comprising these compounds P & G CLAIROL INC (US) 2009-10-14 CN claimed
EP-1670423-B1 DYE-CONTAINING PELLETS FOR DYEING KERATIN FIBRES WELLA AG (DE) 2008-10-08 EP claimed
EP-1601335-B1 MEANS AND METHOD FOR THE SIMULTANEOUS BLEACHING AND DYEING OF KERATIN FIBRES WELLA AG (DE) 2008-03-19 EP claimed
US-7326254-B2 Means and method for the simultaneous bleaching and dyeing of keratin fibres WELLA AG (DE) 2008-02-05 US claimed
EP-1351945-B1 NOVEL 1,4-DIAMINO-2-(THIAZOL-2-YL)BENZENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS WELLA AG (DE) 2008-01-23 EP claimed
CN-100358887-C m-aminophenol derivatives and dyes containing these compounds P & G CLAIROL INC (US) 2008-01-02 CN claimed
CN-101090882-A P-diaminobenzene derivatives and dyes containing these compounds PROCTER & GAMBLE (US) 2007-12-19 CN claimed
US-6042620-A FOR DYEING KERATIN FIBERS SUCH AS HAIR WELLA AG (DE) 2000-03-28 US claimed
US-6004356-A HAIR DYES L'OREAL (FR) 1999-12-21 US claimed
EP-0963982-A2 New diaminobenzene derivatives and these componends containing colouring agents Wella Aktiengesellschaft (DE) 1999-12-15 EP claimed
EP-0943614-A2 Dyeing agents comprising diaminobenzene derivatives and the diaminobenzene derivatives Wella Aktiengesellschaft (DE) 1999-09-22 EP claimed
EP-0853471-A1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES, AND DYEING METHOD USING SAME L'OREAL (FR) 1998-07-22 EP claimed
US-5735909-A Compositions and processes for the oxidation dyeing of keratin fibres with an oxidation base, a meta-aminophenol coupler, and a 6-hydroxyindoline coupler L'OREAL (FR) 1998-04-07 US claimed
WO-1997011674-A1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES, AND DYEING METHOD USING SAME L'OREAL (FR) 1997-04-03 WO claimed
EP-0728465-B1 Composition for dyeing keratinous fibers comprising a meta-aminophenol and 6-hydroxyindoline, and dyeing process using such a composition OREAL (FR) 1997-03-19 EP claimed
EP-0728465-A1 Composition for dyeing keratinous fibers comprising a meta-aminophenol and 6-hydroxyindoline, and dyeing process using such a composition L'OREAL (FR) 1996-08-28 EP claimed
US-4904275-A OXIDIZER L'OREAL (FR) 1990-02-27 US claimed