Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10933576 | 0.83 | CA12 (0.49) | SYKIDO1ADORA3ADORA2AADORA1 | |
| SCHEMBL19440644 | 0.81 | SYK (0.37) | MEN1KMT2AUSP2SYKADORA3 | |
| SCHEMBL28866124 | 0.75 | PABPC1 (0.38) | SYKPOLBMAPTBRD4CREBBP | |
| SCHEMBL17680609 | 0.74 | USP7 (0.41) | USP7POLBMAPTBRD4CREBBP | |
| SCHEMBL16775248 | 0.71 | CREBBP (0.38) | ADORA3ADORA1USP7POLBNPC1 | |
| SCHEMBL7946910 | 0.71 | CYP2A6 (0.42) | MEN1KMT2AADORA3ADORA2AADORA1 | |
| SCHEMBL11061959 | 0.70 | ADRA2A (0.47) | SYK | |
| SCHEMBL19539233 | 0.69 | BRD4 (0.40) | USP7MAPTBRD4CREBBP | |
| SCHEMBL8538647 | 0.69 | KDM4E (0.41) | ADORA2AADORA1USP7POLBNPC1 | |
| SCHEMBL17547027 | 0.69 | CREBBP (0.37) | SYKADORA3ADORA1USP7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781565-A1 | 2-METHYL-AZA-QUINAZOLINES | Bayer Pharma Aktiengesellschaft (DE) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019201848-A1 | 2-METHYL-AZA-QUINAZOLINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-10-24 | — | — | WO | disclosed |