Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26337678 | 0.76 | KDM4E (0.44) | MAPK10KDM4EL3MBTL1RPS6KA3RPS6KA2 | |
| SCHEMBL18412765 | 0.73 | ALDH1A1 (0.48) | KDM4EL3MBTL1RPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL31195969 | 0.73 | CNR2 (0.44) | PIK3CAKDM4ERPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL21495054 | 0.73 | CYP11B1 (0.34) | — | |
| SCHEMBL19105639 | 0.72 | TNIK (0.43) | MAPK10KDM4EL3MBTL1RPS6KA3RPS6KA2 | |
| SCHEMBL21617353 | 0.70 | EGLN2 (0.43) | KDM4ERPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL2123191 | 0.69 | PIK3CA (0.41) | PIK3CA | |
| SCHEMBL18394827 | 0.69 | POLB (0.48) | PIK3CAKDM4EL3MBTL1RPS6KA3RPS6KA2 | |
| SCHEMBL2123449 | 0.69 | PIK3CA (0.40) | PIK3CAKDM4EL3MBTL1 | |
| SCHEMBL2710920 | 0.67 | LGMN (0.46) | PIK3CAKDM4ERPS6KA3RPS6KA2RPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | MASARYKOVA UNIVERZITA (CZ) | 2023-02-21 | — | — | US | disclosed |
| US-20220002282-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2022-01-06 | — | — | US | disclosed |
| CN-112313229-A | Substituted aminothiazoles as inhibitors of nucleases | 马萨里克大学 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019201865-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019201865-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | RNASEH1, DNASE1, FEN1 | PIK3CA 3322/4885MAPK10 4528/4885KDM4E 1848/4885 |
| US-20220002282-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | RNASEH1, DNASE1, FEN1 | PIK3CA 3322/4885MAPK10 4528/4885KDM4E 1848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.