Butane

Butane

SCHEMBL2149677

C1CCC(NC2CCCCC2)CC1.CCCC.Cc1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Butane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.55
TSHR P16473 3/20 0.55
CYP3A4 P08684 2/20 0.55
ADORA3 P0DMS8 1/20 0.51
GAA P10253 2/20 0.50
KCNH2 Q12809 1/20 0.50
LMNA P02545 4/20 0.48
EPHX2 P34913 1/20 0.48
HTT P42858 1/20 0.47
HSD17B10 Q99714 1/20 0.47
POLB P06746 2/20 0.46
TP53 P04637 1/20 0.46
KMT2A Q03164 2/20 0.45
CYP1A2 P05177 2/20 0.44
CYP2C19 P33261 2/20 0.44
HPGD P15428 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
KDM4E B2RXH2 1/20 0.44
PKM P14618 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL631325 0.94 ALDH1A1 (0.61) ALDH1A1TSHRCYP3A4ADORA3GAA
SCHEMBL8999594 0.86 CYP2D6 (0.51) ALDH1A1TSHRCYP3A4ADORA3GAA
Cyclamic Acid SCHEMBL4613995 0.82 ALDH1A1 (0.67) ALDH1A1TSHRCYP3A4ADORA3GAA
Butylcyclohexane SCHEMBL31082847 0.81 CYP1A2 (0.51) ALDH1A1TSHRCYP3A4ADORA3GAA
Butane SCHEMBL27630383 0.80 GAA (0.52) ALDH1A1TSHRCYP3A4GAALMNA
Butane SCHEMBL9425260 0.79 ALDH1A1 (0.50) ALDH1A1TSHRCYP3A4GAALMNA
Cyclopropane SCHEMBL2101355 0.79 GAA (0.54) ALDH1A1TSHRCYP3A4GAALMNA
Cyclohexane SCHEMBL27563472 0.79 GAA (0.54) ALDH1A1TSHRCYP3A4GAALMNA
SCHEMBL11059579 0.78 ALDH1A1 (0.47) ALDH1A1TSHRCYP3A4ADORA3GAA
Cyclohexanol SCHEMBL1553521 0.78 ALDH1A1 (0.51) ALDH1A1TSHRCYP3A4ADORA3GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9290656-B2 Polymerizable composition for polythiourethane optical material MITSUI CHEMICALS, INC. (JP) 2016-03-22 US disclosed
EP-2341091-B1 POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, OPTICAL MATERIAL, AND METHOD FOR PREPARING THE OPTICAL MATERIAL MITSUI CHEMICALS INC (JP) 2013-12-04 EP disclosed
EP-1988109-B1 POLYMERIZABLE COMPOSITION FOR POLYTHIOURETHANE OPTICAL MATERIAL MITSUI CHEMICALS INC (JP) 2013-05-29 EP disclosed
US-8434866-B2 Polymerizable composition for optical material, optical material, and method for preparing the optical material MITSUI CHEMICALS, INC. (JP) 2013-05-07 US disclosed
US-20110190466-A1 POLYMERIZABLE COMPOSITION FOR POLYTHIOURETHANE OPTICAL MATERIAL MITSUI CHEMICALS, INC. (JP) 2011-08-04 US disclosed
EP-2341091-A1 POLYMERIZABLE COMPOUND FOR OPTICAL MATERIAL, OPTICAL MATERIAL, AND OPTICAL MATERIAL MANUFACTURING METHOD Mitsui Chemicals, Inc. (JP) 2011-07-06 EP disclosed
US-20100075154-A1 POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, OPTICAL MATERIAL, AND METHOD FOR PREPARING THE OPTICAL MATERIAL MITSUI CHEMICALS, INC. (JP) 2010-03-25 US disclosed
EP-1988109-A1 POLYMERIZABLE COMPOSITION FOR POLYTHIOURETHANE OPTICAL MATERIAL Mitsui Chemicals, Inc. (JP) 2008-11-05 EP disclosed