Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.48 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | FEN1 | P39748 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22150565 | 0.86 | CHEK2 (0.48) | CHEK2FEN1RORCKMT2A | |
| SCHEMBL16895972 | 0.83 | RPS6KB1 (0.49) | CHEK2RORCKDM4ESCN9A | |
| SCHEMBL16895971 | 0.83 | RPS6KB1 (0.49) | CHEK2RORCKDM4ESCN9A | |
| SCHEMBL21496905 | 0.82 | RORC (0.49) | P2RX3P2RX2CHEK2FEN1RORC | |
| SCHEMBL22121213 | 0.80 | RORC (0.53) | P2RX3P2RX2CHEK2RORCKDM4E | |
| SCHEMBL22150047 | 0.77 | CHEK2 (0.48) | CHEK2RORCKMT2APTGER4 | |
| SCHEMBL5461592 | 0.76 | FEN1 (0.46) | CHEK2FEN1CYP2C9BACE1CTSD | |
| SCHEMBL21496879 | 0.76 | PTGER4 (0.51) | CHEK2KDM4EKMT2AMEN1PTGER4 | |
| SCHEMBL21511698 | 0.76 | PTGER4 (0.51) | CHEK2KDM4EKMT2AMEN1PTGER4 | |
| SCHEMBL29136138 | 0.75 | KMT2A (0.49) | CHEK2FEN1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019204505-A2 | K-RAS MODULATORS WITH A VINYL SULFONAMIDE MOIETY | THERAS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019204505-A2 | K-RAS MODULATORS WITH A VINYL SULFONAMIDE MOIETY | THERAS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |