Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 5/20 | 0.48 |
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22121213 | 0.94 | RORC (0.53) | CHEK2RORCGPR119CNR2KMT2A | |
| SCHEMBL22150047 | 0.91 | CHEK2 (0.48) | CHEK2RORCGPR119KMT2AJAK2 | |
| SCHEMBL22121278 | 0.88 | CHEK2 (0.52) | CHEK2RORCGPR119KMT2AJAK2 | |
| SCHEMBL21496906 | 0.86 | P2RX3 (0.48) | CHEK2RORCKMT2AFEN1 | |
| SCHEMBL22121292 | 0.85 | JAK2 (0.45) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL22135104 | 0.79 | STING1 (0.64) | — | |
| SCHEMBL15576092 | 0.79 | BRD4 (0.47) | JAK3BRD4 | |
| SCHEMBL21310756 | 0.75 | PDE4B (0.49) | CNR2 | |
| SCHEMBL22150548 | 0.73 | IDO1 (0.52) | CHEK2GPR119JAK2JAK3BRD4 | |
| SCHEMBL22151674 | 0.73 | JAK2 (0.47) | KMT2AJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132582-A1 | STING AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |