Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.59 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.50 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 9/20 | 0.49 |
| ▸ | BCR | P11274 | 9/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22543353 | 0.89 | DHODH (0.62) | DHODHTTBK1TTBK2KCNH2SCN5A | |
| SCHEMBL21497177 | 0.79 | EPHX2 (0.48) | DHODHKCNH2SCN9AABL1BCR | |
| SCHEMBL21497143 | 0.79 | CTSC (0.48) | DHODHTTBK1TTBK2KCNH2SCN5A | |
| SCHEMBL26536628 | 0.76 | FFAR4 (0.51) | MEN1KMT2A | |
| SCHEMBL3194551 | 0.75 | MAPT (0.61) | DHODHTTBK1TTBK2KCNH2SCN5A | |
| SCHEMBL1923201 | 0.75 | MAPT (0.61) | DHODHTTBK1TTBK2KCNH2SCN5A | |
| SCHEMBL15146260 | 0.74 | MAPT (0.56) | DHODHTTBK1TTBK2KCNH2SCN5A | |
| SCHEMBL23607654 | 0.74 | EPHX2 (0.56) | DHODHTTBK1TTBK2KCNH2SCN5A | |
| SCHEMBL30012613 | 0.74 | EPHX2 (0.56) | DHODHTTBK1TTBK2KCNH2SCN5A | |
| SCHEMBL20553261 | 0.74 | HPGD (0.63) | DHODHTTBK1TTBK2KCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | claimed |
| EP-3781165-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | Virginia Tech Intellectual Properties, Inc. (US) | 2021-02-24 | — | — | EP | claimed |
| CN-112261941-A | Aminopyrazines and related compounds useful as mitochondrial uncouplers | 弗吉尼亚理工大学知识产权有限公司 | 2021-01-22 | — | — | CN | claimed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | claimed |
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | GLS2, NDUFAF1, NDUFAB1 | DHODH 3533/4885TTBK1 4065/4885TTBK2 3717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.