Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18427056 | 0.88 | HPGDS (0.60) | HPGDSHDAC2HDAC1HDAC3KCNH2 | |
| SCHEMBL21132341 | 0.87 | PRKD1 (0.52) | SMOHPGDSERN1BMPR1BBMPR1A | |
| SCHEMBL6769761 | 0.82 | HPGDS (0.70) | HPGDSKCNH2USP30 | |
| Hydrochloric Acid SCHEMBL20293639 | 0.79 | HDAC2 (0.55) | HDAC2HDAC1HDAC3KCNH2IKBKE | |
| SCHEMBL15244966 | 0.77 | KCNH2 (0.56) | HDAC2HDAC1HDAC3KCNH2BMPR1B | |
| SCHEMBL15244897 | 0.77 | KCNH2 (0.56) | HDAC2HDAC1HDAC3KCNH2BMPR1B | |
| SCHEMBL1745423 | 0.74 | L3MBTL3 (0.46) | SMOHDAC1ACVR1 | |
| SCHEMBL15615176 | 0.74 | SMO (0.75) | SMOHPGDSHDAC2HDAC1HDAC3 | |
| SCHEMBL16812022 | 0.74 | SMO (0.83) | SMOHPGDSHDAC2HDAC1HDAC3 | |
| SCHEMBL15615178 | 0.74 | DYRK1A (0.65) | SMOL3MBTL1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450286-B2 | Compounds and compositions for inhibition of FASN | FORMA THERAPEUTICS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450286-B2 | Compounds and compositions for inhibition of FASN | FASN, FABP1, SCD | SMO 4621/4885HPGDS 959/4885HDAC2 3288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.