Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29067123 | 0.88 | LTA4H (0.63) | CYP3A4ALDH1A1LTA4HMAOBLMNA | |
| SCHEMBL22746281 | 0.85 | ALDH1A1 (0.66) | CYP3A4ALDH1A1LTA4HDHFRMAOB | |
| SCHEMBL9177757 | 0.78 | ALDH1A1 (0.51) | CYP3A4ALDH1A1DHFRMAPTCYP19A1 | |
| SCHEMBL7004918 | 0.78 | CYP19A1 (0.67) | CYP3A4ALDH1A1LTA4HMAOBMAOA | |
| SCHEMBL8136072 | 0.78 | TAAR1 (0.61) | CYP3A4ALDH1A1LTA4HDHFRMAOB | |
| SCHEMBL29067121 | 0.77 | CA2 (0.69) | CYP3A4ALDH1A1LTA4HCYP1A2DHFR | |
| SCHEMBL3482569 | 0.76 | CA1 (0.62) | CYP3A4ALDH1A1CYP17A1MAOBKDM4E | |
| SCHEMBL29569802 | 0.76 | CA1 (0.62) | CYP3A4ALDH1A1CYP17A1MAOBKDM4E | |
| SCHEMBL9719373 | 0.76 | CA1 (0.62) | CYP3A4ALDH1A1CYP17A1MAOBKDM4E | |
| SCHEMBL30324526 | 0.76 | CA1 (0.62) | CYP3A4ALDH1A1CYP17A1MAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689346-B2 | Human plasma kallikrein inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190322626-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322626-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK1, KLK5 | CYP3A4 1447/4885ALDH1A1 1065/4885LTA4H 452/4885 |
| US-10689346-B2 | Human plasma kallikrein inhibitors | KLKB1, KLK1, KLK5 | CYP3A4 1447/4885ALDH1A1 1065/4885LTA4H 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.