Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29969803 | 1.00 | JAK2 (0.44) | JAK2JAK3JAK1OPRK1MAP4K4 | |
| SCHEMBL21494392 | 0.92 | OPRK1 (0.47) | JAK2JAK3JAK1OPRK1 | |
| SCHEMBL30866880 | 0.92 | OPRK1 (0.47) | JAK2JAK3JAK1OPRK1 | |
| SCHEMBL21513231 | 0.89 | HRH3 (0.42) | JAK2JAK3JAK1OPRK1HRH4 | |
| SCHEMBL4673381 | 0.86 | MAP4K4 (0.43) | JAK2JAK3JAK1OPRK1MAP4K4 | |
| SCHEMBL390676 | 0.85 | OPRK1 (0.44) | JAK2JAK3JAK1OPRK1HRH4 | |
| SCHEMBL390675 | 0.85 | OPRK1 (0.44) | JAK2JAK3JAK1OPRK1HRH4 | |
| SCHEMBL26130781 | 0.79 | JAK2 (0.43) | JAK2JAK3JAK1OPRK1HRH4 | |
| SCHEMBL29968129 | 0.79 | JAK2 (0.43) | JAK2JAK3JAK1OPRK1HRH4 | |
| SCHEMBL21513238 | 0.79 | OPRK1 (0.48) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |