Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5604031 | 0.98 | LMNA (0.57) | LMNAPOLBKCNH3TDP1L3MBTL1 | |
| SCHEMBL28315014 | 0.98 | LMNA (0.57) | LMNAPOLBKCNH3TDP1L3MBTL1 | |
| SCHEMBL31066863 | 0.98 | LMNA (0.57) | LMNAPOLBKCNH3TDP1L3MBTL1 | |
| SCHEMBL31066874 | 0.98 | LMNA (0.57) | LMNAPOLBKCNH3TDP1L3MBTL1 | |
| SCHEMBL4507702 | 0.95 | LMNA (0.53) | LMNAPOLBKCNH3TDP1L3MBTL1 | |
| SCHEMBL15922756 | 0.89 | LMNA (0.50) | LMNAPOLBKCNH3TDP1L3MBTL1 | |
| SCHEMBL3643530 | 0.87 | RAB9A (0.54) | LMNAPOLBRAB9ATRPV1ALDH1A1 | |
| SCHEMBL11490915 | 0.83 | LMNA (0.52) | LMNAPOLBKCNH3TDP1L3MBTL1 | |
| Pyridine SCHEMBL14855721 | 0.81 | KCNH3 (0.55) | LMNAPOLBKCNH3RAB9AGBA1 | |
| Pyridine SCHEMBL27500063 | 0.81 | KCNH3 (0.55) | LMNAPOLBKCNH3RAB9AGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016014390-A1 | COMPOSITIONS AND METHODS FOR MEK INHIBITOR COMBINATION THERAPY IN THE TREATMENT OF CANCER | MERCK PATENT GMBH (DE) | 2016-01-28 | — | — | WO | claimed |
| US-4718934-A | PLANT GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1988-01-12 | — | — | US | claimed |
| CN-104788365-B | Pyrazinamide derivative, preparation method and application | 上海艾力斯医药科技有限公司 | 2018-08-10 | — | — | CN | disclosed |
| US-9975853-B2 | Tetrahydroisoquinolinone derivatives and their use in the inhibition of the HSP70 protein | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2018-05-22 | — | — | US | disclosed |
| US-20170152229-A1 | TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2017-06-01 | — | — | US | disclosed |
| WO-2016014390-A1 | COMPOSITIONS AND METHODS FOR MEK INHIBITOR COMBINATION THERAPY IN THE TREATMENT OF CANCER | MERCK PATENT GMBH (DE) | 2016-01-28 | — | — | WO | disclosed |
| CN-104788365-A | Isonicotinamide derivative, preparation method and applications thereof | ALLIST PHARMACEUTICALS INC | 2015-07-22 | — | — | CN | disclosed |
| US-9045429-B2 | Substituted phenoxypyridines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-06-02 | — | — | US | disclosed |
| CN-101065358-B | 3-arylamino pyridine derivatives | MERCK SERONO SA | 2015-03-11 | — | — | CN | disclosed |
| CN-101065358-B | 3-arylamino pyridine derivatives | MERCK SERONO SA | 2015-03-11 | — | — | CN | disclosed |
| CN-101065358-B | 3-arylamino pyridine derivatives | MERCK SERONO SA | 2015-03-11 | — | — | CN | disclosed |
| US-20090093462-A1 | 3-Arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2009-04-09 | — | — | US | disclosed |
| CN-101065358-A | 3-arylamino pyridine derivatives | APPLIED RESEARCH SYSTEMS (AN) | 2007-10-31 | — | — | CN | disclosed |
| CN-101065358-A | 3-arylamino pyridine derivatives | APPLIED RESEARCH SYSTEMS (AN) | 2007-10-31 | — | — | CN | disclosed |
| CN-101065358-A | 3-arylamino pyridine derivatives | APPLIED RESEARCH SYSTEMS (AN) | 2007-10-31 | — | — | CN | disclosed |
| EP-1802579-A1 | 3-ARYLAMINO PYRIDINE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2007-07-04 | — | — | EP | disclosed |
| EP-1802579-A1 | 3-ARYLAMINO PYRIDINE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006045514-A1 | 3-ARYLAMINO PYRIDINE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2006-05-04 | — | — | WO | disclosed |
| WO-2006045514-A1 | 3-ARYLAMINO PYRIDINE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2006-05-04 | — | — | WO | disclosed |
| US-4117135-A | NOVEL 5,6,7,8-TETRAHYDRO-5-QUINOLINES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING, A.G. | 1978-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152229-A1 | TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN | HSPH1, HSP90AB1, HSP90AB2P | LMNA 4452/4885POLB 2845/4885KCNH3 4506/4885 |
| US-20090093462-A1 | 3-Arylamino pyridine derivatives | CDK4, BRAF, CDK3 | LMNA 2488/4885POLB 2155/4885KCNH3 3223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.