Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 10/20 | 0.47 |
| ▸ | ACACA | Q13085 | 9/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419702 | 0.87 | ACACB (0.49) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL29106587 | 0.86 | DRD2 (0.56) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL13419736 | 0.85 | CKS1B (0.46) | CKS1BSKP1SKP2DRD2 | |
| SCHEMBL25172520 | 0.84 | MAPT (0.40) | KDM4E | |
| SCHEMBL4288052 | 0.82 | ACACB (0.47) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL4288054 | 0.82 | ACACB (0.47) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL28180990 | 0.82 | PIM1 (0.48) | CKS1BSKP1SKP2SUV39H2 | |
| SCHEMBL31333729 | 0.82 | ACACB (0.46) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL5653703 | 0.81 | CKS1B (0.53) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL1750143 | 0.80 | RBP4 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3403651-B1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | LANZHOU INST CHEMICAL PHYSICS CAS (CN) | 2019-10-30 | — | — | EP | disclosed |