Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31260097 | 0.83 | CYP11B1 (0.55) | CYP11B2CYP11B1 | |
| SCHEMBL14789911 | 0.83 | CYP11B1 (0.55) | CYP11B2CYP11B1 | |
| SCHEMBL22005290 | 0.76 | CYP11B2 (0.51) | CYP11B2CYP11B1 | |
| SCHEMBL21535354 | 0.76 | PDK1 (0.46) | PDK1PDK2PDK3PDK4CYP11B2 | |
| SCHEMBL21535156 | 0.72 | CYP11B2 (0.40) | CYP11B2CYP11B1 | |
| SCHEMBL22004587 | 0.72 | CYP11B2 (0.41) | CYP11B2CYP11B1 | |
| SCHEMBL22004705 | 0.72 | CYP11B2 (0.46) | CYP11B2CYP11B1 | |
| SCHEMBL21535304 | 0.71 | CYP11B2 (0.51) | CYP11B2CYP11B1 | |
| SCHEMBL22004749 | 0.71 | CYP11B2 (0.39) | CYP11B2CYP11B1 | |
| SCHEMBL22004689 | 0.70 | CYP11B1 (0.42) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755963-B1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-10-30 | — | — | EP | disclosed |