Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913345 | 0.84 | LMNA (0.60) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL23980138 | 0.84 | MAPT (0.45) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL18641828 | 0.84 | MAPT (0.45) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL1692203 | 0.81 | SLC6A2 (0.60) | ADRA2CMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1692389 | 0.81 | SLC6A2 (0.60) | ADRA2CMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11077174 | 0.79 | LMNA (0.54) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL8037032 | 0.77 | LMNA (0.52) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL2736639 | 0.77 | LMNA (0.50) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL7914382 | 0.77 | AOC3 (0.58) | LMNAAOC3ADRA2CKDM4EADRA2A | |
| SCHEMBL23980139 | 0.77 | LMNA (0.50) | LMNAAOC3ADRA2CKDM4EADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190330239-A1 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2019-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330239-A1 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | DGAT2, DGAT1, MOGAT2 | LMNA 4148/4885AOC3 1356/4885ADRA2C 1190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.