Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 2/20 | 0.36 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | UGCG | Q16739 | 1/20 | 0.33 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 2/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21034207 | 0.83 | RXRA (0.33) | RXRARXRBRXRGL3MBTL1MRGPRX4 | |
| SCHEMBL21033756 | 0.83 | RXRA (0.33) | RXRARXRBRXRGL3MBTL1MRGPRX4 | |
| SCHEMBL21033755 | 0.83 | RXRA (0.33) | RXRARXRBRXRGL3MBTL1MRGPRX4 | |
| SCHEMBL21539820 | 0.81 | RXRA (0.34) | RXRARXRBRXRGMRGPRX4NOTUM | |
| SCHEMBL21556805 | 0.80 | L3MBTL1 (0.35) | L3MBTL1UGCGPDE10ABTKATM | |
| SCHEMBL21034307 | 0.80 | RXRA (0.36) | RXRARXRBRXRGMRGPRX4NOTUM | |
| SCHEMBL21034301 | 0.80 | NISCH (0.34) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL21034310 | 0.80 | LMNA (0.44) | L3MBTL1SGMS2 | |
| SCHEMBL21539729 | 0.80 | L3MBTL1 (0.34) | L3MBTL1UGCGPDE10ABTK | |
| SCHEMBL21539746 | 0.79 | SLC5A1 (0.33) | RXRARXRBRXRGMRGPRX4MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919908-B2 | Thienopyrimidinone derivative and application thereof in preparing anticancer drug | HENAN GENUINE BIOTECH CO., LTD. (CN) | 2021-02-16 | — | — | US | disclosed |
| EP-3567043-A1 | THIENOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MANUFACTURING OF ANTITUMOR DRUGS | Henan Genuine Biotech Co., Ltd. (CN) | 2019-11-13 | — | — | EP | disclosed |
| US-20190330230-A1 | THIENOPYRIMIDINONE DERIVATIVE AND APPLICATION THEREOF IN PREPARING ANTICANCER DRUG | HENAN GENUINE BIOTECH CO., LTD. (CN) | 2019-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919908-B2 | Thienopyrimidinone derivative and application thereof in preparing anticancer drug | CCND3, CCND1, CCND2 | RXRA 3013/4885RXRB 2587/4885RXRG 3354/4885 |
| US-20190330230-A1 | THIENOPYRIMIDINONE DERIVATIVE AND APPLICATION THEREOF IN PREPARING ANTICANCER DRUG | CCND3, CCND1, CCND2 | RXRA 3013/4885RXRB 2587/4885RXRG 3354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.