SCHEMBL2154387

SCHEMBL2154387

Cc1cccc(P(Cl)c2cccc(C)c2)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.55
ALDH1A1 P00352 1/20 0.44
MAPK1 P28482 1/20 0.44
TP53 P04637 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
NPC1 O15118 1/20 0.38
CASP3 P42574 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TSHR P16473 2/20 0.37
PARP1 P09874 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2154530 0.93 ACHE (0.48) ACHEALDH1A1MAPK1TP53TDP1
SCHEMBL2368527 0.84 ACHE (0.55) ACHEALDH1A1MAPK1TP53TDP1
SCHEMBL29415924 0.78 ACHE (0.61) ACHEALDH1A1MAPK1TP53TDP1
SCHEMBL49786 0.78 ACHE (0.61) ACHEALDH1A1MAPK1TP53TDP1
SCHEMBL5713327 0.76 ACHE (0.58) ACHEALDH1A1MAPK1TP53TDP1
SCHEMBL18423870 0.76 ACHE (0.58) ACHEALDH1A1MAPK1TP53TDP1
SCHEMBL8849287 0.76 ACHE (0.58) ACHEALDH1A1MAPK1TP53TDP1
Bromide SCHEMBL8849644 0.76 ACHE (0.58) ACHEALDH1A1MAPK1TP53TDP1
Hydrochloric Acid SCHEMBL4529394 0.76 ACHE (0.58) ACHEALDH1A1MAPK1TP53TDP1
Iodide SCHEMBL28418605 0.76 ACHE (0.58) ACHEALDH1A1MAPK1TP53TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0403188-B1 A compound of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and catalytic complexes thereof TAKASAGO PERFUMERY CO LTD (JP) 1994-12-07 EP claimed
EP-0403188-A2 A compound of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and catalytic complexes thereof Takasago International Corporation (JP) 1990-12-19 EP claimed
EP-3260460-B1 LIGAND COMPOUND, ORGANIC CHROME COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND METHOD FOR OLEFIN OLIGOMERIZATION USING SAME LG CHEMICAL LTD (KR) 2021-09-08 EP disclosed
US-10392451-B2 Ligand compound, organic chromium compound, catalyst system for olefin oligomerization, and method for oligomerizing olefins using the same thereof LG CHEM, LTD. (KR) 2019-08-27 US disclosed
EP-3184171-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2019-03-20 EP disclosed
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2018-12-04 US disclosed
US-9962689-B2 Phosphinyl formamidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2018-05-08 US disclosed
US-20180086860-A1 LIGAND COMPOUND, ORGANIC CHROMIUM COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND METHOD FOR OLIGOMERIZING OLEFINS USING THE SAME LG CHEM, LTD. (KR) 2018-03-29 US disclosed
EP-3260460-A1 LIGAND COMPOUND, ORGANIC CHROME COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND METHOD FOR OLEFIN OLIGOMERIZATION USING SAME LG Chem, Ltd. (KR) 2017-12-27 EP disclosed
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP 2017-10-26 US disclosed
US-9732106-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2017-08-15 US disclosed
US-8680003-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2014-03-25 US disclosed
US-20120309965-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-12-06 US disclosed
EP-2519532-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS Chevron Phillips Chemical Company LP (US) 2012-11-07 EP disclosed
WO-2011082192-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2011-07-07 WO disclosed
US-20050288257-A1 Novel stable compositions of water and oxygen sensitive compounds and their method of preparation NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2005-12-29 US disclosed
US-6084133-A REACTING A PHOSPHINE HALIDE WITH A METAL, THEN PROTONATION RESULTING DIORGANO-SUBSTITUTED METAL PHOSPHIDE; SIMPLIFICATION, NONTOXIC, EFFICIENCY KANKYO KAGAKU CENTER CO., LTD. (JP) 2000-07-04 US disclosed
EP-0403188-B1 A compound of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and catalytic complexes thereof TAKASAGO PERFUMERY CO LTD (JP) 1994-12-07 EP disclosed
US-5012002-A 2,2'-bis(di-(m-tolyl)phosphino)-1,1'-binaphthyl TAKASAGO INTERNATIONAL CORPORATION (JP) 1991-04-30 US disclosed
EP-0403188-A2 A compound of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and catalytic complexes thereof Takasago International Corporation (JP) 1990-12-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180086860-A1 LIGAND COMPOUND, ORGANIC CHROMIUM COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND METHOD FOR OLIGOMERIZING OLEFINS USING THE SAME OXER1, OSTC, ORC3 ACHE 113/4885ALDH1A1 2408/4885MAPK1 2545/4885
US-10392451-B2 Ligand compound, organic chromium compound, catalyst system for olefin oligomerization, and method for oligomerizing olefins using the same thereof OXER1, OSTC, ORC3 ACHE 116/4885ALDH1A1 1855/4885MAPK1 2303/4885
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins NIT2, NCLN, NPM1 ACHE 1107/4885ALDH1A1 4849/4885MAPK1 1845/4885
US-20120309965-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 ACHE 1107/4885ALDH1A1 4849/4885MAPK1 1845/4885
US-20050288257-A1 Novel stable compositions of water and oxygen sensitive compounds and their method of preparation COXFA4L2, CYP2F1, ABCG2 ACHE 483/4885ALDH1A1 964/4885MAPK1 3732/4885
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 ACHE 1107/4885ALDH1A1 4849/4885MAPK1 1845/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.