SCHEMBL21546830

SCHEMBL21546830

Cc1cc(C)c(-c2ccc3c4ccccc4n(-c4cc(-c5cccc(C#N)c5)cc(-n5c6ccccc6c6ccc(-c7c(C)cc(C)cc7C)cc65)c4C#N)c3c2)c(C)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 1/20 0.34
PDE9A O76083 1/20 0.34
PDE1C Q14123 1/20 0.34
GRIA2 P42262 1/20 0.34
GRIA4 P48058 1/20 0.34
PGR P06401 2/20 0.34
ADORA2A P29274 3/20 0.33
ADORA1 P30542 3/20 0.33
ADORA2B P29275 2/20 0.33
PLG P00747 1/20 0.32
PLAU P00749 1/20 0.32
MAP4K4 O95819 1/20 0.32
GSK3A P49840 1/20 0.32
CHEK1 O14757 1/20 0.32
ALDH1A1 P00352 3/20 0.32
CYP1A2 P05177 3/20 0.32
CYP3A4 P08684 3/20 0.32
CLK4 Q9HAZ1 3/20 0.32
MEN1 O00255 2/20 0.32
CYP2C19 P33261 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546824 0.96 GRIA2 (0.36) ALDH1A3GRIA2GRIA4PGRADORA2A
SCHEMBL21546823 0.95 PTGER4 (0.35) ALDH1A3PDE9APDE1CGRIA2GRIA4
SCHEMBL21414241 0.93 PDE9A (0.36) PDE9APDE1CPGRALDH1A1MAPK1
SCHEMBL21546832 0.91 GRIA2 (0.37) ALDH1A3GRIA2GRIA4PGRADORA2A
SCHEMBL21546790 0.89 ALDH1A1 (0.37) ALDH1A3PDE9APDE1CGRIA2GRIA4
SCHEMBL21547133 0.89 SYK (0.37) ALDH1A3PGRPLGPLAUMAP4K4
SCHEMBL21546619 0.89 ALDH1A3 (0.34) ALDH1A3PDE9APDE1CGRIA2GRIA4
SCHEMBL21546826 0.88 ELANE (0.35) ALDH1A3PDE9APDE1CGRIA2GRIA4
SCHEMBL21546721 0.87 ADORA2A (0.36) ALDH1A3PDE9APDE1CGRIA2GRIA4
SCHEMBL21414245 0.87 CHEK1 (0.32) PGRCHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed