SCHEMBL21546831

SCHEMBL21546831

Cc1ccc(-c2ccc3c(c2)c2ccccc2n3-c2cc(-c3cccc(C#N)c3)cc(-n3c4ccccc4c4cc(-c5ccc(C)cc5C)ccc43)c2C#N)c(C)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.35
ALDH1A1 P00352 3/20 0.34
CYP1A2 P05177 3/20 0.34
CHEK1 O14757 1/20 0.34
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HSD17B10 Q99714 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
PTGER4 P35408 1/20 0.34
PGR P06401 3/20 0.33
ALDH1A3 P47895 1/20 0.33
PDE9A O76083 1/20 0.33
PDE1C Q14123 1/20 0.33
CYP3A4 P08684 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546826 0.94 ELANE (0.35) ELANEALDH1A1CYP1A2CHEK1KDM4E
SCHEMBL21414174 0.93 PDE9A (0.35) ALDH1A1KDM4ELMNATP53HPGD
SCHEMBL22760664 0.92 PDE9A (0.31) ELANEALDH1A1CYP1A2KDM4ELMNA
SCHEMBL21546817 0.91 ADRA2C (0.36) ALDH1A1CYP1A2CHEK1PTGER4PGR
SCHEMBL22760917 0.91 ELANE (0.33) ELANEALDH1A1CYP1A2CHEK1KDM4E
SCHEMBL21546821 0.90 PGR (0.35) ELANEALDH1A1CYP1A2CHEK1KDM4E
SCHEMBL21546789 0.90 ALDH1A1 (0.39) ELANEALDH1A1CYP1A2KDM4ELMNA
SCHEMBL21546717 0.90 ADORA2A (0.36) ELANEALDH1A1CYP1A2KDM4ELMNA
SCHEMBL21547158 0.90 PDK2 (0.37) ELANEALDH1A1CYP1A2CHEK1KDM4E
SCHEMBL21546823 0.89 PTGER4 (0.35) ALDH1A1CYP1A2KDM4ELMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed