SCHEMBL21546855

SCHEMBL21546855

Cc1ccc2c3ccc(C)cc3n(-c3cc(C#N)c(-c4cccc(C#N)c4)cc3-n3c4cc(C)ccc4c4ccc(C)cc43)c2c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.38
BRD4 O60885 1/20 0.37
F11 P03951 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP3A4 P08684 2/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2C19 P33261 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GABRA1 P14867 1/20 0.35
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35
GABRA3 P34903 1/20 0.35
GABRA2 P47869 1/20 0.35
ADRA2C P18825 1/20 0.35
CLK4 Q9HAZ1 3/20 0.35
DYRK1A Q13627 1/20 0.35
ALDH1A3 P47895 1/20 0.34
LRRK2 Q5S007 2/20 0.34
USP2 O75604 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546667 0.92 PGR (0.37) BRD4F11CYP1A2CYP3A4CLK4
SCHEMBL21546662 0.92 AR (0.41) ELANEBRD4F11CYP1A2CYP3A4
SCHEMBL21546587 0.92 ELANE (0.39) ELANEBRD4F11CYP1A2CYP3A4
SCHEMBL21546848 0.90 ELANE (0.38) ELANEBRD4F11CYP1A2CYP3A4
SCHEMBL21547069 0.90 ADRA2C (0.38) BRD4CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL22760967 0.89 ALDH1A3 (0.39) BRD4CYP1A2CYP3A4ADRA2CCLK4
SCHEMBL21546601 0.89 ELANE (0.38) ELANEBRD4F11CYP1A2CYP3A4
SCHEMBL21546851 0.89 ELANE (0.38) ELANEBRD4F11CYP1A2CYP3A4
SCHEMBL21546675 0.88 ELANE (0.38) ELANEF11CYP1A2CYP3A4CYP2D6
SCHEMBL21546677 0.88 ALDH1A3 (0.37) ELANEBRD4CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed