Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 2/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21548828 | 0.82 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1GAAL3MBTL1CASP3 | |
| Hydrochloric Acid SCHEMBL21526063 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1GAAENPP1CASP3 | |
| SCHEMBL21548807 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL21548812 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL20356660 | 0.73 | ADORA3 (0.35) | SMN1; SMN2ALDH1A1L3MBTL1ENPP1CASP3 | |
| SCHEMBL20356519 | 0.72 | MAPK8 (0.38) | SMN1; SMN2ALDH1A1MAPK1MAPTL3MBTL1 | |
| SCHEMBL21548960 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTENPP1NPC1 | |
| Hydrochloric Acid SCHEMBL21526105 | 0.72 | ADORA3 (0.34) | SMN1; SMN2ALDH1A1L3MBTL1ENPP1CASP3 | |
| Hydrochloric Acid SCHEMBL21526076 | 0.71 | MAPK8 (0.38) | SMN1; SMN2ALDH1A1MAPK1MAPTL3MBTL1 | |
| SCHEMBL20356657 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1GAAMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |